LIFESCI 3 Lecture Notes - Lecture 12: Histone H2B, Euchromatin, Chromatin
Document Summary
Chromatin, chromatid(after synthesis and condense), chromosome(condensed even more after separation), eukaryotes- gentic material located in the nucleus attached to histone. Each string is a dna wrapped around a histone = chromatin. Interphase(before cell division when all the genetic material is spread out) Nucleosome= 8 core histones(h1, h3, h2a, h2b) wrapped around with dna twice important core histone is h1 linker. Represses or inhibites trxn by preventing trxn factors from binding to dna byy histone binding to dna itself. inhibite decondensation. Experiment(what promoter in enhancer region looks like compared to other regions of dna) Chromatin remodeling - architecture where, how dense, how do chromatin fold? change this stuff. Beginning with same core histones, remodeler protein comes along, repositions nucelesome to create nucleosome free region where another remodel replaces h2a with h2a. z using freee region, better stable free region to allow for trax. Histone modified add acetyl group, methyl, phosphate, ubq to histone, and chromatin less condensed to histone tails.
