BIOL 1107 Lecture Notes - Lecture 3: Logarithmic Scale

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yellowcoyote790

2 Sep 2016

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Acid base reactions and ph: ph is a measure of h ion concentration is a solution, proton (hydrogen ion (h+)) concentration is the basis of the ph scale. Ph expresses proton concentration in a solution: the ph of pure water is 7. Bases have a ph greater than 7. We can detect this bc of equivalence of scale. By using ph scale we can detect logarithmic scale so we can interpret large amounts of ions then detect changes in ph. Ph=-log(h+: in acid-base reactions, a proton donor (acid) transfers a proton to a proton acceptor (base, if substances brought into water they break a part, so we have to regulate that. When placed in water items give up h atoms, when in high concentrations make solutions acidic making it toxic to living things. If readily taking substances in we have to control the acidification of body by using buffers.

Related Questions

Living systems can be studied by way of the scientific method which involves which of the following?

Using only deductive reasoning and not inductive reasoning

Using few subjects, but repeating the experiments and using controls

Using few subjects, but repeating the experiments

Using many subjects, but doing no statistical analysis

Using many subjects but having no controls

Which of the following molecules has the least amount of energy that you can use for intense physical exercise?

A chemically specifically designed to signal uncontrolled cell growth

Water since it promotes all chemical reactions

Lipids

Carbohydrates

Protein

Nicotine produced in plants can be lethal to insects in that it causes a paralysis. Where does nicotine have its effect?

Nicotine receptors located in the nucleus of the cell

Nicotine receptors on the plasma membrane of brain cells

Nicotine receptors in the golgi bodies of neurons

Nicotine receptors on the mitochondria of brain cells

The aqueous (water) space between cells is which of the following?

Blood

Interstitial

Extracellular

Intracellular

All of these answers are correct

A hypo-osmotic solution can be defined as which of the following?

A solution separated from another by way of semipermeable membrane in which the hyposmotic solution has less electrolyes and more water than the other solution

A solution separated from another by way of semipermeable membrane in which the hyperosmotic solution has less electrolyes and more water than the other solution

A solution that is equal in concentration compared to another

A solution that is less concentrated relative to another

A solution that is more concentrated relative to another

Lactic acid in your muscles is the byproduct of which metabolic pathway?

Glycolysis

Electron Transport System

Krebs cycle

Glycolysis and oxygen

Which of the following best describes the process of glycolysis?

A series of chemical reactions in the mitochondria that breakdown or catabolize glucose to produce ATP without oxygen

A series of chemical reactions that breakdown or catabolize protein to produce lactic acid in the presence of oxygen

A series of chemical reactions in the muscle cytoplasm that breaksdown or catabolize glucose to produce ATP without oxygen

A series of chemical reactions that produce enzymes

During oxidative phosphorylation, which of the following is phosphorylated with the assistance of ATP synthase?

Cytochromes

ADP

ATP

NADH

Hydrogen ions

In all animals who use oxidative phorphorylation to generate ATP, the ultimate electron acceptor is directly transported to all cells by way of which of the following?

Hemoglobin

Red blood cells

Water (H2O)

Lungs

After NADH is reduced at the Electron Transport system, the hydrogen ion subsequently does which of the following?

Activates ATPsynthase

Activates Krebs cycle

Activates chemiosmosis

Oxidizes ATP

Reduces ATP

Which of the following has to exist for ATP synthase to be activated to directly produce ATP?

An oxygen gradient

A neutron gradient

An electron gradient

A proton gradient

All of these answers are correct

Which of the following occurs when oxyhemoglobin reaches the capillaries of heart muscle?

Releases oxygen which leaves the capillary and diffuses into the cell

Absorbs oxygen from the mitochondria

Releases its oxygen which diffuses from the mitochondria to the capillary

Releases its oxygen which diffuses from the capillary to the nucleus

Need help with biology questions:

1. To increase the excretion of an acidic drug, what would you do to the urine?

	A.	Make it more basic
	B.	None of the above
	C.	Make it neutral
	D.	Make it more acidic

2. G-Protein coupled receptors directly act on which of the following secondary messenger molecules:

	A.	cAMP
	B.	ATP
	C.	ADP
	D.	GTP
	E.	None of the above or more than one of the above

3. Drug A and Drug B both produce the same level of biological/physiological response. Drug A produces this effect with 100 mg/kg dose. Drug B produces this effect with 50 mg/kg dose. Which of the following is true?:

	A.	Drug B is more efficacious than Drug A. Both drugs are equally potent.
	B.	Drug A is more efficacious than Drug B. Both drugs are equally potent.
	C.	Drug A and B are equally efficacious. Drug A is more potent than Drug B.
	D.	Drug A and B are equally efficacious. Drug B is more potent than Drug A.

4. The stomach has a ______ pH, whereas the small intestines have a _______ pH. The colon has an approximately ___________ pH.

	A.	High; low; neutral
	B.	Low; high; neutral
	C.	Low; neutral; neutral
	D.	None of the above

5. Which receptor is most likely to reduce norepinephrine levels when activated?

	A.	alpha 2 adrenergic
	B.	alpha 1 adrenergic
	C.	dopamine D1 receptors

6. Which of the following statements are FALSE?

	A.	If the Vd of a drug is between 60 and 80 L the drug has likely distributed to the total body water of a 200 kg man.
	B.	In the enterohepatic system the activity of bacteria to remove conjugates from a drug in the gut will decrease the clearance of the drug.
	C.	Lipid drugs are more likely to be reabsorbed by the kidney from the urine.
	D.	A weak basic drug (pKa = 6) will be mostly ionized in urine of a pH= 3 and only the non- ionized drug will be eliminated.
	E.	The major conjugate in Phase 2 metabolism is glucuronide.

7. Isoproterenol (Î²-agonist) is a vasodilator that increases HR. What happens to systolic and diastolic pressures upon IV administration of isoproterenol?

	A.	â systolic; â diastolic
	B.	â systolic; â diastolic
	C.	â systolic; â diastolic
	D.	â systolic; â diastolic
	E.	None of the above

8. If you want to increase the blood concentration of a drug A, you can perform which of the following procedures:

	A.	Inhibit Drug A metabolism with Drug B
	B.	Enhance Drug A reabsorption from renal proximal tubule by changing ionization of Drug A with Drug B
	C.	Allow competition of Drug B with Drug A for active renal secretion processes
	D.	Increase the binding of Drug A to serum albumin
	E.	All of the above

9. Which of the following describes Phase I metabolism?

	A.	Inactive products are always produced in this phase.
	B.	Large molecules such as glucuronic acid are conjugated to drugs in this phase.
	C.	This phase may produce active metabolites from prodrugs.
	D.	This phase only occurs in the liver.

10. Which of the following is NOT an enzyme involved in the biosynthesis of biogenic amines?

	A.	Phenylethanolamine N-methyl Transferase
	B.	Dopamine Î²-hydroxylase
	C.	Tyrosine dehydroxylase
	D.	DOPA decarboxylase
	E.	All of the above

11. Why would an antibiotic at the same concentration be more active against bacteria in water than in serum or plasma? (Activity is measured in a test tube)

	A.	activity of the antibiotic is increased in water.
	B.	due to drug-protein interaction in serum
	C.	the antibiotic is more stable in water
	D.	all of the above
	E.	none of the above

12. Ion channels are targets for drugs. Which drug class targets Na+ channels?

	A.	Benzodiazepines
	B.	Beta blockers
	C.	Local anesthetics
	D.	Antihypertensive drugs (cardiac and smooth muscle)
	E.	Glibenclimide (diabetic drug)

13. _________________ not metabolized by catechol-O-methyltransferase (COMT).

	A.	Dopamine
	B.	Epinephrine
	C.	Phenylephrine
	D.	Norepinephrine
	E.	All of the above are metabolized by COMT.

2. Letâs consider transport of iodine (I- ) into your thyroid cells. You need iodine in your diet for normal thyroid activity, but dietary iodine concentrations are very low (usually in America we get enough just from what is added to iodized salt). People have been interested for some time in trying to figure out how we can transport iodine so efficiently. One way we can study the transporter is to look for mutations that alter its function, and therefore lead to thyroid problems.

A. The transporter is a rocker-switch type Na+ / Isymport. The pivot of the rocker mechanism is a glycine amino acid, #93 in the primary structure of the transporter. Some people with thyroid problems have a mutation that changes this glycine to an arginine. Define what is meant by âthe primary structureâ of the transporter. Explain how that change would alter the function of the transporter. (You may consult the structure of arginine on slide 7 of Lecture 3.)

B. There is normally an Arginine at position #124 in the primary structure of the transporter. This Arginine participates in hydrogen bonding with an Asparagine, positioned at #441 in the primary structure. There is evidence that these H-bonds are present in the outward-facing transporter conformation, but are broken when the transporter switches to the inward-facing conformation. People with mutations that replace Arginine 124 with Histidine have difficulty transporting Iodine into their thyroid cells. Copy the structures of Arginine and Asparagine. Label relevant H-bond donor and acceptor atoms between these two amino acids. Explain how replacing Arginine 124 with Histidine could affect the operation of the transporter. (Make a sketch of the transporter in the inward-facing and outward-facing conformations to help you to visualize this.)

C. Recent investigation demonstrated that there are actually TWO Na+ ions symported with the Iion. When a colleague of mine saw this report, he said âAh ha! So thatâs why iodine transport is so efficient!â Explain why it would make a difference whether one or two sodium ions were involved? Why would involving two sodium ions make the transporter more efficient?

BIOL 1107 Lecture Notes - Lecture 3: Logarithmic Scale

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