DIET 4475 Lecture Notes - Lecture 51: Acute-Phase Protein, Serum Iron, Myoglobin
Document Summary
Iron function: delivers o2 to cells, component of hgb and myoglobin, hgb: carries o2 to cells and takes co2 away from cells, myoglobin: enhances amount of o2 needed for muscle contraction, atp production, drug metabolism. Immune function: the acute phase response (apr) to injury and infection. Serum iron levels are suppressed and iron transport is depressed, while serum ferritin levels increase. The body is hoarding iron into a storage form following injury and infection. It reduces the availability of iron for iron-dependent microorganism proliferation, especially gram-negative bacilli. Iron also reduces free radical production and oxidative damage to membranes and dna. Standard parenteral trace element products do not include iron in part to avoid potential contribution to microbial growth and damaging oxidative reactions. Iron recommendations: men: 8 mg, pre-menopausal women: 18 mg, post-menopausal women: 8 mg, pregnancy: 27 mg, lactation: 9 mg, at-risk for deficiency:
