ANFS332 Lecture Notes - Lecture 5: Systemic Lupus Erythematosus, Superoxide Dismutase, Rheumatoid Arthritis
22 Sep 2019
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Document Summary
About 30 proteins are induced by inflammation. Many of these proteins are synthesized by hepatocytes approx. 90 mins after an inflammatory reaction is initiated. Serum amyloid p - formation of immunoglobulin complexes. Superoxide dismutase - formation of reactive oxygen species. Mobilizes effector cells and molecules to the site. The response can sometimes be out of proportion to the threat. The result can be more damage to the body than what the agent would have caused. Examples are many types of allergies and autoimmune diseases. On occasions the inflammatory response - usually to an infection lipopolysaccharides (lps) breasing gram-negative bacteria - spirals out of control progressing until it involves the entire body. One result is a breakdown in the control of blood clotting. What should have been a mechanism to help wall off an infected area and promote healing leads instead to a dangerous deposition of fibrin in small blood vessels throughout the body. A failure of many organs (lungs, kidneys)
