ANFS332 Lecture Notes - Lecture 13: Adaptive Immune System, Cell-Mediated Immunity, Cd14
27 Nov 2016
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Primary and secondary lymphoid tissues, antigen, antibody kinetics, clonal selection. What happens? (toll-like receptors: example: tlr4 and lps, lps binds to lbp (lipopolysaccharide binding protein). The lps-lbp complex binds to cd14: as a consequence of the cd14-lbp/lps interaction at the level of the membrane, Tlr-4 plays an important signaling role: tlr-4 activates a transcription factor known as nkfb. Nkfb activation eventually leads to transcriptional activation resulting in the synthesis of: Too much of a good thing: excessive activation of tlr is hazardous, and leads to overproduction of inflammatory cytokines and endotoxin shock. Therefore, tlr signaling is tightly regulated by various mechanisms including a negative regulator, irak-m. In the absence of irak-m, mice and cells show excessive inflammatory response. wild- type and irak-m deficient mice were infected orally with bacteria (salmonella typhimurium(cid:895) a(cid:374)d the i(cid:374)testi(cid:374)al pe(cid:455)er"s pat(cid:272)hes (cid:449)ere stai(cid:374)ed (cid:449)ith he(cid:373)ato(cid:454)ili(cid:374) Note the extreme inflammation accompanied by hemorrhage in the.
