MCB 150 Lecture Notes - Lecture 30: Microfilament, Dynamical System, Cytoskeleton
7 Apr 2017
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Document Summary
Dynamic system of protein fibers of various sizes. Dynamic because the cell can change length. Provides physical support and allows for movement. Actin monomers are highly folded, globular proteins. Polymerization happens in both directions and it is irreversible. Atp actin has high affinity, and it also has a pause before hydrolysis. This explains favorable polymerization at the barbed end. Adp actin has low affinity and wants to fall off, this explains the higher depolymerization at the pointed end. This is explained on the video he posted. The microfilament will be polymerizing at both ends. The microfilament will be depolymerizing at both ends. The microfilament will be polymerizing at the plus end and depolymerizing at the minus end. The microfilament will be polymerizing at the minus end and depolymerizing at the plus end. The microfilament will be depolymerizing at the plus end and exhibiting no net growth at the minus end.
