BIOL 2P03 Lecture Notes - Lecture 18: Endocytosis, Cell Membrane, Formins
27 Feb 2016
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Document Summary
Cellular contents are organized in a specific fashion. Proteins located in appropriate regions based on their assigned functions. The cytoskeleton is a filamentous network of proteins consisting of: The cytoskeleton is a dynamic system that can reorganize itself to meet the changing needs of the cell. Structure: microfilaments are made up of the protein actin, monomers of actin are globular and are known as g-actin, g-actin monomers can be polymerized into filamentous structures known as f-actin. G-actin monomers non-covalently bind to each other to form f-actin. The g-actin monomers that make up f-actin each contain an atp/adp binding site. The orientation of these binding sites differs at each end of f-actin. The polymerization of g-actin to form f-actin can be studied in vitro. Purified atp-g-actin is present in solution at a defined concentration. If this concentration is high enough, atp-g-actin will spontaneously polymerize to form f-actin. The process of actin polymerization can be broken down into three stages:
