BIOS 222 Lecture Notes - Lecture 20: Receptor Tyrosine Kinase, Protein Kinase B, Tyrosine
Document Summary
Activated rtks recruit a complex of intracellular signaling proteins. Receptor tyrosine kinases- if kinase is called tyrosine kinase, it"s phorsphorylated on tyrosines. Tyrosine kinases type of receptor that has enzymatic activity. Enzyme coupled-receptors, coupled means going to interact with something directly as part of its main action. Individual polypeptides, mirror images of eachother in pm, individual units that phosphorylate eachother. Sig molecs can vary dep on type of receptor kinase that it is. Range from fairly small to larger growth factor type of molec proteins that are going to interact with external facing part of individual receptors. Once they come together close enough for good binding. Know what inactive tyrosine kinase looks like and an active receptor tyrosine kinase. Shown in fig 16/12 because shows initial activation of rec. dep on rtk, multiple phosphorylation sites. Almost always, each phosph sites have further interaction with some kind of signaling protein. Powerful rec in terms of spreading info quickly and multp types.
