BIOLOGY 151 Lecture Notes - Lecture 22: Glycolysis, Pyruvic Acid, Alpha-Ketoglutaric Acid

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21 Dec 2015
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After glycolysis, the action shifts to the mitochondrial matrix. Three carbons so two for each molecule of glucose. Pyruvate comes out of glycolysis, enters the mitochondria. As it gets oxidized going to give off co2. Tca has two main purposes: anabolic: produces carbon skeletons for lipids, amino acids, nucleotides, catabolic: nadh from nad+, some atp. The first run through does not get rid of any of the carbons in the pyruvate. The second and third run through get rid of the carbon, one at a time. Products of the citric acid cycle: nadh/ fadh2, atp/gtp, co2. Peter mitchell proposed that a mechanism kind of like a waterfall or hydroelectric dam responsible for the production of atp. The chemiosmotic production of atp is in two stages both in mitochondria: Stage 1 protons (h+) are pumped across the membrane like storing water behind a dam, then the rush of the protons back is harnessed to create atp.

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