MICROBIO 160 Lecture Notes - Lecture 26: Magic Johnson Foundation, Viral Load, Opportunistic Infection

• School: UMASS-Amherst
• Department: Microbiology
• Course: MICROBIO 160
• Professor: Wilmore Welby

Document Summary

Nrtis put in a faulty base on the dna chain. Nnrtis do not interfere with the base, but it binds to the reverse transcriptase enzyme and inhibits it so it cannot create the bases. *these are by far the most effective drugs against hiv. The main difference between the two is how they work. If you inhibit the protease, it does not allow the virus to bud out. Inhibited protease prevents cleavage of the polypeptide and subsequent maturation of the virion. T20 peptides prevent the conformational change and prevent the hairpin structure. Fusion is prevented and viral entry is blocked. Fusion or entry inhibitors*** yet fda approved) (fda approved 2003). Fuzeon***: peptide that binds to gp41 preventing hiv from binding to surface of t-cells. Selzentry***: ccr5-blocking entry inhibitor (approved by fda august 2007). Vicriviroc & pro140: binds ccr5, preventing the virus from infecting healthy cells (not. Tnx-355: experimental monoclonal antibody that targets the cd4 protein on helper.