BIOL 483 Lecture Notes - Lecture 38: Srcap, Cenpa, Prc2
Document Summary
When you have h3. 3s31ph, this stimulates p300, which is h3k27ac mark but also for elongation specifically, mark can also be read by setd2 to lead to deposition in reading of. M residues can"t be methylated -> mutation decreases methylation. It also has allosteric effects on prc2, so normally h3k27me3 can bind to prc2 to activate it and serve as spreader of marks. But h3k27m oncohistone -> binds to active site and prevents catalysis and stalls prc2 to reduce h3k27 methylation everywhere. Facultative heterochromatin can encode genes and can be hetero or euchraomtin. In inactive x chromosomes, barr bodies, one can be silenced to maintain appropriate dosage of genes, but they don"t have to be heterochromatic/ can also be euchromatic. Along cenpa lines, ben black is a cool prof. Takes repetitive or non repetitive dna treated with hjurp and cenpa histones to make artificial centromeres. If underlying dna is repetitive dna or non repetitive dna it can happen.
