BIO 346 Lecture Notes - Lecture 9: Allele Frequency, Neurodegeneration, Bar Chart
Document Summary
Heritability - how much of the variation among people is due to the variation in genes. Allele frequency - totals of each row. If same (null and observed) in hardy-weinberg equilibrium. E3/e3 - occuring less than expected, and e4/e4 occurring more. E4 allele is also rare already more rare when multiplied together for 2 alleles + az already rare. Fraction of people who have az is what matters rather than the number of people who get it overall with the allele. How much does having one apoe4 allele increase your risk of az relative to null expectation? (calculate?) Ex: estimate frequencies of phenotypic values associated with different genotypes mri images to quantify degeneration corrected for age for az. Graphing association between e3 or e4 alleles and neurodegeneration. X axis (independent variable) - genotype / alleles. If you think e4 is a risk allele can number 0-2. Y axis (dependent variable) - amount of neurodegeneration.
