BCMB 230 Lecture Notes - Lecture 20: Warfarin, Cardiac Surgery, Channel Types
16 Dec 2016
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11/8/16
• Anticlotting
• Thrombumodulin→ Protein C
• Tissue Factor Inhibitor
• Collateral Circulation- Heart Attack- blood flow to the heart; stroke- blood flow to the
brain Clots to the kidney- Many small clots
• How do we stop the clotting?
• Figure 12.76
• Antithrombrin/heparin helps shut down the cascade
• ANOTHER CLOTTING SYSTEM
o Fibrinolytic system- Removes clots
o Figure 12.77
o Plasmin chops fibrin into pieces making it water soluble
o Table 12.15
o Table 12.14
• 5 categories of function
• Platelet Activation
• Inhibition of platelets
• Clotting
• Anticlotting
• Fibrinolytic
STUDY TOOL: FACTOR→ WHERE MAJOR CLASS→ SPECIFIC ACTION
• Liver plays a big role in clotting Figure 12.75
• Vitamin K- Assists in blood clotting
• Calcium Important in clotting
• DRUGS THAT INFLUENCE CLOTTING
o Stitches enhance clotting
o So after cardiac surgery they give you warfarin to reduce clotting, via vitamin K
absorption inhibition. Warfarin found in rat poison
o Must work with vitamin K consumption- Leafy green vegetables
o Figure 5.12
o Asprin inhibits cyclooxygenase.- Anticoagulate?- Acts preventatively
o A small dose of aspirin
o Prostraglandins→ Endothileal cells→ Can make more enzyme for inflammation
o Thromboxanes→ Platelets→ No nucleus→ ca’t ake ore eze for clotting
• Big picture of blood pressure and flow
o Systemic
o Local
o Intrinsic factors- Inside the organ- Inside- Advantage
o Exercise activates fight or flight- Exercising one muscle= combination of both
local and systemic control
o Short term regulation of blood pressure—vasoconstriction
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