BIOL 1105 Lecture Notes - Lecture 17: Amniocentesis, Bloodborne, Centimorgan

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Explain how study of sex-linked inheritance in fruit flies. First suggested role for chromosomes in heredity. Chromosomes are the carriers of genetic information and the basis for genetic inheritance. Provided first evidence that genes resided on chromosomes. Conducted genetic studies of the fruit fly. Discovered a mutant male fly with white eyes instead of red. Crossed the mutant male to a normal red-eyed female. All f1 progeny had red eyes red eye color was the dominant trait. Describe how sex chromosomes are important for sex. Recessive alleles on the male"s x have no counterpart on the y. Requires sry gene on y chromosome for male. Male produces x and y containing gametes. Affects a single protein in the cascade of proteins involved in the formation of blood clots. Form of hemophilia is caused by an x-linked recessive allele. Allele for hemophilia was introduced into a number of european female families.

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