BIO 1140 Lecture Notes - Lecture 18: Phoebus Levene, Friedrich Miescher, Gregor Mendel
Document Summary
Nucleic acids are polymers also known as polynucleotides. Each polynucleotide is made of monomers called nucleotides. Dna in prokaryotic cell are unbound and thus do not have a nucleus. Pea breeder extraordinaire and the father of modern genetics. Isolated a phosphate rich molecule he named nuclein from white blood cells. Identified the composition of a nucleotide and how a polynucleotide was assembled. Nucleotides are the building blocks of nucleic acids. It imparts a negative charge to nucleic acids. The phosphate is attached to the c5" hydroxyl of the sugar. The nitrogenous base is attached at c1". Ribose in the case of rna (oh present c2") There are 2 types of nitrogenous bases. Purines have a six-membered ring fused to a five-membered ring. A dehydration reaction joins adjacent nucleotides by forming a phosphodiester bond between the. Oh group on the 3" carbon of one nucleotide and the phosphate at the 5" carbon on the next.
