BIOLOGY 2C03 Chapter Notes - Chapter 5: Thomas Hunt Morgan, Gene Mapping, Chromosome
Document Summary
Molbio 2c03: chapter 5 genetic linkage and mapping in eukaryotes. Thomas hunt morgan won a noble prize for work establishing the chromosome theory of inheritance & also for identifying & explaining genetic linkage & recombination. He applied linkage and recombination to genetic mapping. There are thousands (or tens of thousands) of genes located on a few chromosomes => each chromosome must contain multiple gene. Synthetic genes - genes located on the same chromosome (and in specific order) Alleles of synthetic genes can be reshuffled when crossing over occurs between. Linked genes synthetic genes so close together their alleles cannot sort independently homologs to produce recombinant chromosomes. Homologs that do not reshuffle alleles under study are called parental chromosomes or nonrecombinant chromosomes. Genetic linkage mapping plots the positions of genes and their relative distances from each other on chromosomes. Recombination frequency, expressed as r, is calculated as.
