BPK 304 Lecture Notes - Orthodenticle Homeobox 2, Hox Gene, Bone Morphogenetic Protein

• School: Simon Fraser University
• Department: Department of Humanities Biological Sciences
• Course: BISC 333

Document Summary

Expression of otx 2 and gbx 2 in non-overlapping domain. Otx 2 in fore/mid brain and gbx2 in hindbrain/spinal cord. Signalling centres anr and mhb produces fgf-8. Shh from notochord and floor plate pattern neural tube along d/v axis. Commissural axons at dorsal, interneurons and mv at ventral. Bmp from overlying ectoderm and shh from notochord induces signalling centres (floor and roof plate) that send further signals to pattern d/v. Shh acts as a morphogen (low shh induces v1,v2 and high shh induces mv) Shh represses class i tfs and induces class ii tfs. Mutual repression of both sharpens the border and leads to a unique combination of tfs. Often arises from borders between two territories. Mhb organizer: arises a border between otx2 expression domain and gbx2 expression domain. When transplants mbh organizer, it induces mid and hindbrain structure in forebrain. Shh and fgf leads to expression of transcription factors such as emx2 (at p) and pax 6 (at a)