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MBB 222 Lecture 10: Lecture 10 &11 notes

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graysea-lion876
12 Mar 2022
School
Simon Fraser University
Department
Molec Biol & Biochem
Course
MBB 222
Professor

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Document Summary

Proteins the engines of life mediatemostcellularprocesses sass of alldrugstarget proteins moresequence and chemicalcomplexitythandiva or run propertiesandstructuredefinedby the sequenceandsidechainsoftheirconstituent a as. Levelsof proteinstructure fadedproteinstructure is stabilizedby weakinteraction gelectrostatic now nbonds disulfidebondsbitcysteineresidue. Hnt aminogroup h aminoacids buildingblocks of proteins carboxygroup psidechain. 20differentnaturallyoccurring a a eachw diff k group every a ahas acarboncovalently attached to 4 diet substituents aminocamme groupcarboxygroupsidechainhydrogen. Cahas spshybridization tetrahedrongeometry a singlecosbond at ioas toeachother. Cahas 4diff groups carboxyl amino r group andhydrogen. Laira i assymetric isomersof a a mirrorimage ofeachother are called. 2 d for dextorotary zo naturally occurring aas are lisomers. Qhowto tellwhich aas are l or r isomers. H carboxy amino iclockwise i isomers icounterclockwise r isomers au aas exceptglycineare chirae has 2hs sidechainsof 20naturally occurring aas. 4polar verycharged r groups sipolar verycharged r groups smallestsidechains glycine andalanine leaststerichindrancedue to size glycine flexible achiral modernhydrophobic aliphatichydrophobic nonpolar sidechains hydrophobic foundininteriorposition of protein hydrophobicityeabilitytomovefrompolar to nonpolarenvironment.

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Related Questions

Protein Structure

a.Different function of proteins and examples:

b. Protein building blocks:

1. atomic composition of building block:

2. "parts" or "functional groups" of the building block:

c. Importance of side chain (R group):

d. Hydrophobic amino acids characteristics:

e. Hydrophilic amino acids characteristics:

f. Charged amino acids characteristics

Copy and complete the table below regarding the characteristics and which groups in the polypeptide interact together at each structural level of the protein.

characteristics

groups interacting

Primary structure

Secondary structure

Tertiary structure

Quartenary structure

Value: 2

Choose the correct statement(s). You may choose more than one answer.

[mark all correct answers]
a. Proteins are the building blocks of amino acids.

b. Enzymes are a type of protein.

c. Quartenary structure consists of two or more polypeptide chains interacting.

d. Amino acids are made of carbon, hydrogen, nitrogen and phosphorus.

e. The primary structure of a protein is formed due to the interaction of side groups.

Value: 3

Put the following statements regarding the structural levels of a protein formation in the correct order.

Below is a sequence of events. Place them in the order they should occur, number 1 being the first item. Select the step number from the drop down next to each item.

Items to order:

1. Individual amino acids are bonded together via peptide bonds.

2. Two or more polypeptide chains interact via bonds.

3. Hydrogen bonds form between neighboring amino acids within a polypeptide chain allowing the chain to coil or form pleated sheets.

4. Side groups (R) of the individual amino acids interact with each other allowing the protein to assume its three dimensional shape.

Value:4

Put the following statements regarding the structural levels of a protein formation in the correct order

Individual amino acids are bonded together via peptide bonds.

 1 2 3 4

Two or more polypeptide chains interact via bonds.

 1 2 3 4

Hydrogen bonds form between neighboring amino acids within a polypeptide chain allowing the chain to coil or form pleated sheets.

 1 2 3 4

Side groups (R) of the individual amino acids interact with each other allowing the protein to assume its three dimensional shape.

 1 2 3 4

Value: 5

Hydrophobic amino acids will be found _______________.

a. In the interior (inner core) of a protein, away from the watery environment.

b. in the interior of a plasma membrane.

c. Both A and B

d. Neither

Value: 6

A protein's function is defined by ____________.

a. enzymatic reactions

b. it's shape.

c. chain of nucleotides.

d. the presence of carbon and hydrogen.

Value: 7

Which of the following is NOT considered a protein function?

a. transport of substances across membrane

b. enzymatic reactions

c. provides structural support

d. carries genetic information

thank you

The sequence of amino acids is considered to be the ________ structure of a protein.

Select one:

a. secondary

b. tertiary

c. quaternary

d. primary

The pattern the backbone folds, for example alpha-helix or beta pleated sheet, is the ________ structure of a protein.

Select one:

a. quaternary

b. secondary

c. tertiary

d. primary

Which type of forces stabilizes the primary structure of a protein?

Select one:

a. Salt bridges

b. Hydrogen bonding between the carbonyl group and amino group

c. Dipole-dipole

d. Peptide bonds

The interaction of the side chains on the amino acids, for example hydrophobic attractions, is the ________ structure of a protein.

Select one:

a. quaternary

b. secondary

c. tertiary

d. primary