BIO251H1 Lecture Notes - Lecture 1: Flavin Adenine Dinucleotide, Succinate Dehydrogenase, Electrochemical Gradient
Document Summary
This is by creating the electrochemical gradient which generate free energy potential called proton motive force. This occurs mitochondria in both cellular respiration and photosynthesis. The usual order of complexes in the etc is; complex i, ii, iii, and complex iv. Complex i (nadh-q oxidoreductase) or (nadh: ubiquinone reductase) This is made up of nadh dehydrogenase donated from glycolysis and citric acid cycle, flavin mononucleotide (fmn) derived from vitamin b2 a prosthetic group, and eight (8) iron-sulfur cluster. This is the largest protein complex of about 900 kd in size with 46 unique peptides chains and l-shaped protein embedded in the bio-membrane. Nadh is oxidized to nad+ by transfer of h+ and 2-electrons which are received by fe-s, which are therefore transferred finally to coenzyme q. Hence capable of pumping four protons (4h+) to the inter-membrane space which increases the electrochemical gradient of hydrogen ions to the adjacent compartment. Complex i plays in the apoptosis a programed cell death.
