BLG 699 Lecture Notes - Biological Pathway, Model Organism, Pharmacokinetics
Document Summary
Lecture 7: pre clinical testing and animal testing (part 1) What are three r"s and its impact. With an animal model, scientists looking at changes (e. g. biochemical, etc. ) is easier than if you were to analyze something through a computer or a dish. At the same time, tests being performed could be used to treat animal illnesses and diseases. All procedures, even those classified as mild , have the potential to cause the animals physical as well as psychological distress and suffering. Most animals are killed at the end of an experiment, but some may be reused in subsequent experiments. An ideal drug is potent, efficacious, and specific; that is, strong effects on a specific targeted biological pathway and minimal effects on all other pathways, to reduce side effects. In reality, no drugs are perfectly effective and absolutely safe. Depends on the chemical and structural specificity of drug target interaction (we look at its affinity)
