BIOL 240 Chapter Notes - Chapter 4: Adrenergic Receptor, Adenylyl Cyclase, Signal Transduction
Document Summary
Biosignaling (from lehninger) signal transduction - signal represents information that is detected y specific receptors and converted to a cellular response, which always involves a chemical process. Specificity: achieved by precise molecular complementarity between the signal and receptor molecules, mediated by the same kinds of weak (noncovalent) forces that mediate enzyme-substrate ad antigen-antibody interactions. Specificity is further achieved by the presence of. open and close in response to the binding of in transmembrane ligands or changes chem. potential. E. g. acetylcholine receptor ion channel: adhesion receptors. Ecm and convey instructions to the cytoskeletal system about cell migration or adherence to matrix. Bind specific ligands and alter the rate at w/c specific genes are transcribed and ranslated into receptors in certain cell types only cellular proteins. The receptor detects picomolar concentrations of a dignal molecule. 3 essential components that define signal transduction through. In receptor-ligand interactions, results in large changes in receptor activation with small changes in ligand.
