Biology 2382B Lecture Notes - Endocytosis, Secretion, Transferrin Receptor
Document Summary
Learning objectives transport vesicles transport between rer and cis-golgi (dxe, kdel, kkxx) protein sorting signals. Where do proteins go after er: proteins go into er some go secretory pathway outside cell but some go to non-secretory and end up in the organelles of the cell. Overview of secretory and endocytic pathways of protein sorting: proteins are synthesized as they are attached to er membrane proteins enter into lumen either move from er golgi apparatus outside cell, or organelle (lysosome) Gtp binding proteins control assembly and disassembly of copii coat proteins: membrane associated gtp binding proteins promote association of. **gtp binding proteins + bound gtp = critical for recruitment of coat proteins to form. Rer to cis-golgi transport: copii vesicles mediate anterograde transport. Cop2 golgi apparatus hydrolysis and gtp takes off coat proteins and gtp binding proteins snare proteins promote fusion of vesicle membrane w golgi membrane atp hydrolysis for snare proteins to disassemble.
