PSYC62H3 Chapter Notes - Chapter 4: Pharmacokinetics, Pharmacodynamics, Primary Stages

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These different methods of use do not change how cocaine acts in the brain, but they do determine how quickly cocaine reaches the brain. Thus, pharmacokinetic issues explain the common administration methods for cocaine: pharmacodynamics refers to how drugs cause biological changes in the body. The route of administration is an important determinant for how much drug reaches the bloodstream (vertical axis, shown as a percentage of drug) and the length of time needed for drug absorption (horizontal axis). This figure shows different administration routes for a fictional drug. The time needed for elimination will vary from drug to drug, but the general pattern tends to be the same. membranes: diffusion works best for non-ionized drug molecules, which have a neutral ph (i. e. , ph = However, the drug with a pka of 8 will absorb more readily in the intestines where the ph is.

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