Chapter : Inmunologia - 2 Activacion, diferenciacion y generacion de memoria de Celulas B

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linayui

18 Dec 2022

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UCLA

Department

Medicine

Course

MED 19

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Activaci n de c lulas b, diferenciaci n y generaci n de memoria: linfocitos b inmaduros con receptores de ig en superficie > especificidad identica, estimulacion con antigeno: celula b migra a organos linfoides 2rios y se replica. > clona con mismo receptor y anticuerpos que secreta tienen especificidad identica: celulas b de memoria. Celulas b con receptores para antigenos propios eliminadas en desarrollo embrionario. Mediada por celulas b b-2 (mayoritarias) que se unen a antigenos td. Antigenos de espacios tisulares drenados por sist. linfatico filtrados por ganglios linfaticos regionales. Grandes: atrapadas por macrofagos scs > actividad fagocitica limitada. Ti-1: lps gram [-] > interactua con celula b por medio de mig por emdio de receptores inmunitarios innatos. Son mitogenos: inducen proliferacion de celulas b a concentraciones altas . A concentraciones bajas activan a celulas b que se unen a antigeno con receptores ig.

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indicate whether you think the statements are true or false, and explain your reasoning. In each of your answers, provide 1-2 specific examples that support your position. (Each of your four answers is worth five points):

A) Memory cells require fewer distinct signals to be activated than naiÌve cells require.

B) Both B cells and T cells undergo âclonal selectionâ after they are activated by antigen.

C) A B cell is only able to present antigen to a T cell that includes the epitope to which the

B cellâs receptor bound.

D) T cells can recognize peptide antigens in the context of MHC I and MHC II regardless of

whether they are Thelper or Tcytotoxic cells.

E) B cells and T cells can both still make productive antigen receptors via V(D)J

recombination even if no P-nucleotides are introduced during the process.

F) Allelic exclusion takes place when a naiÌve T or B cell encounters its specific non-self antigen for the first time and determines whether or not to become activated.

G) B cells have more chances to make a productively rearranged antigen receptor than T cells do.

H) A majority of immature T cells developing in the thymus will survive both positive and negative selection.

I) The reason why T cells are the only type of white blood cell that requires maturation in a specialized organ outside the bone marrow is because they are the only ones that must have antigen processed and presented to them before they can be activated.

violetbear615

Like T cells, B cells require multiple signals for activation. Antigen binding to the B cell antigen ______ provides one signal, while antigen-specific effector ______ provide the other signals. The requirement for multiple signals to activate either a T cell or a B cell helps to prevent ______ and dangerous activation of monocytes , including ______ ______ . Most of the proteins involved in cellâcell recognition and antigen recognition in the immune system, including ______, TCRs, and ______ proteins, as well as various co-receptors, belong to the ancient Ig superfamily. This superfamily is thought to have evolved from a primordial gene encoding a single Ig- like ______ . The mechanisms for diversifying antibodies and T cell receptors by recombining gene segments may have arisen when a ______ inserted into an exon of a gene encoding an Ig family member.

receptors (BCRs) helper T cells killer T cells
inappropriate appropriate monocytes
lymphocytes self-reactive non-self-reactive
antibodies IPR MHC
domain transposon retrovirus

tanmacaw520

Fill in the blanks in the following paragraph using words from the word bank below. Not all words will be used, and some may be used more than once.

Like T cells, B cells require multiple signals for activation. Antigen binding to the B cell antigen __________provides one signal, while antigen-specific effector ________ provide the other signals. The requirement for multiple signals to activate either a T cell or a B cell helps to prevent _______ and dangerous activation of _________ , including __________ _________. Most of the proteins involved in cellâcell recognition and antigen recognition in the immune system, including _________ , TCRs, and _______ proteins, as well as various co-receptors, belong to the ancient Ig superfamily. This superfamily is thought to have evolved from a primordial gene encoding a single Ig- like _______ . The mechanisms for diversifying antibodies and T cell receptors by recombining gene segments may have arisen when a _________ inserted into an exon of a gene encoding an Ig family member.

receptors (BCRs) helper T cells killer T cells
inappropriate appropriate monocytes
lymphocytes self-reactive non-self-reactive
antibodies IPR MHC
domain transposon retrovirus

plumsquirrel992

Chapter : Inmunologia - 2 Activacion, diferenciacion y generacion de memoria de Celulas B

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