Describe the polarity and the structure of water molecules. What are hydrogen bonds?
Define salinity.
What are the dissolved components in seawater (use table 5.1)?
What processes decrease salinity?
What processes increase salinity?
Why is ice less dense than water? What is the formula for density?
If seawater salinity increases, what happens to the density?
If SST decreases what happens water density?
Is seawater acidic or basic?
What is the pH of seawater?
Describe the polarity and the structure of water molecules. What are hydrogen bonds?
Define salinity.
What are the dissolved components in seawater (use table 5.1)?
What processes decrease salinity?
What processes increase salinity?
Why is ice less dense than water? What is the formula for density?
If seawater salinity increases, what happens to the density?
If SST decreases what happens water density?
Is seawater acidic or basic?
What is the pH of seawater?
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1. To increase the excretion of an acidic drug, what would you do to the urine?
A. | Make it more basic | |
B. | None of the above | |
C. | Make it neutral | |
D. | Make it more acidic |
2. G-Protein coupled receptors directly act on which of the following secondary messenger molecules:
A. | cAMP | |
B. | ATP | |
C. | ADP | |
D. | GTP | |
E. | None of the above or more than one of the above |
3. Drug A and Drug B both produce the same level of biological/physiological response. Drug A produces this effect with 100 mg/kg dose. Drug B produces this effect with 50 mg/kg dose. Which of the following is true?:
A. | Drug B is more efficacious than Drug A. Both drugs are equally potent. | |
B. | Drug A is more efficacious than Drug B. Both drugs are equally potent. | |
C. | Drug A and B are equally efficacious. Drug A is more potent than Drug B. | |
D. | Drug A and B are equally efficacious. Drug B is more potent than Drug A. |
4. The stomach has a ______ pH, whereas the small intestines have a _______ pH. The colon has an approximately ___________ pH.
A. | High; low; neutral | |
B. | Low; high; neutral | |
C. | Low; neutral; neutral | |
D. | None of the above |
5. Which receptor is most likely to reduce norepinephrine levels when activated?
A. | alpha 2 adrenergic | |
B. | alpha 1 adrenergic | |
C. | dopamine D1 receptors |
6. Which of the following statements are FALSE?
A. | If the Vd of a drug is between 60 and 80 L the drug has likely distributed to the total body water of a 200 kg man. | |
B. | In the enterohepatic system the activity of bacteria to remove conjugates from a drug in the gut will decrease the clearance of the drug. | |
C. | Lipid drugs are more likely to be reabsorbed by the kidney from the urine. | |
D. | A weak basic drug (pKa = 6) will be mostly ionized in urine of a pH= 3 and only the non- ionized drug will be eliminated. | |
E. | The major conjugate in Phase 2 metabolism is glucuronide. |
7. Isoproterenol (β-agonist) is a vasodilator that increases HR. What happens to systolic and diastolic pressures upon IV administration of isoproterenol?
A. | â systolic; â diastolic | |
B. | â systolic; â diastolic | |
C. | â systolic; â diastolic | |
D. | â systolic; â diastolic | |
E. | None of the above |
8. If you want to increase the blood concentration of a drug A, you can perform which of the following procedures:
A. | Inhibit Drug A metabolism with Drug B | |
B. | Enhance Drug A reabsorption from renal proximal tubule by changing ionization of Drug A with Drug B | |
C. | Allow competition of Drug B with Drug A for active renal secretion processes | |
D. | Increase the binding of Drug A to serum albumin | |
E. | All of the above |
9. Which of the following describes Phase I metabolism?
A. | Inactive products are always produced in this phase. | |
B. | Large molecules such as glucuronic acid are conjugated to drugs in this phase. | |
C. | This phase may produce active metabolites from prodrugs. | |
D. | This phase only occurs in the liver. |
10. Which of the following is NOT an enzyme involved in the biosynthesis of biogenic amines?
A. | Phenylethanolamine N-methyl Transferase | |
B. | Dopamine β-hydroxylase | |
C. | Tyrosine dehydroxylase | |
D. | DOPA decarboxylase | |
E. | All of the above |
11. Why would an antibiotic at the same concentration be more active against bacteria in water than in serum or plasma? (Activity is measured in a test tube)
A. | activity of the antibiotic is increased in water. | |
B. | due to drug-protein interaction in serum | |
C. | the antibiotic is more stable in water | |
D. | all of the above | |
E. | none of the above |
12. Ion channels are targets for drugs. Which drug class targets Na+ channels?
A. | Benzodiazepines | |
B. | Beta blockers | |
C. | Local anesthetics | |
D. | Antihypertensive drugs (cardiac and smooth muscle) | |
E. | Glibenclimide (diabetic drug) |
13. _________________ not metabolized by catechol-O-methyltransferase (COMT).
A. | Dopamine | |
B. | Epinephrine | |
C. | Phenylephrine | |
D. | Norepinephrine | |
E. | All of the above are metabolized by COMT. |