1.What are MITE elements and how they may regulate gene expression?
2.Look for examples: TATA containing and TATA less genes, mRNA coding for same protein and have different 5âUTR or 3âUTR (give and example of both). What roll does different 5â or 3â UTR may have in these mRNAs?
1.What are MITE elements and how they may regulate gene expression?
2.Look for examples: TATA containing and TATA less genes, mRNA coding for same protein and have different 5âUTR or 3âUTR (give and example of both). What roll does different 5â or 3â UTR may have in these mRNAs?
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Part B
Think about the DNA coding sequence of a gene. If an A were swapped for a T, what kind of mutation could it cause and why?
| a) It could cause a frameshift nonsense or frameshift missense mutation because it would change the reading frame of the codon triplet. | ||||||||||||||||||||||||||||
| b) It could cause a silent, missense, or nonsense mutation because those are the types that can be caused by a nucleotide-pair substitution like this one. | ||||||||||||||||||||||||||||
| c) It could cause a nonsense mutation because the sequence would no longer be the same, so the protein would be shorter and non-functional. | ||||||||||||||||||||||||||||
| d) It could cause a silent mutation because A and T are complementary to each other so it is not really a substitution mutation. Part C Why is a frameshift missense mutation more likely to have a severe effect on phenotype than a nucleotide-pair substitution missense mutation in the same protein?
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