How is it that post-synaptic calcium entry regulates both strengthening (Long-term potentiation) and weakening (long term depression)?
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Describe four mechanisms by which Calcium entry into the post-synaptic cell leads to strengthening of the synapse.
What ions, and under what conditions, are permeable across the membrane when AMPA receptors are activated? When NMDA receptors are activated?
Long-term potentiation (LTP) exhibits cooperativity, selectivity and associativity.
a.) Briefly explain what each of these terms means in the context of LTP and how the properties of NMDA receptors give rise to these three features of LTP.
b.) Propose one or more experiments that could test whether hippocampal LTP is required for learning and/or memory. Include a brief description of possible results and how you would interpret the results.
What are the differences in the cellular mechanisms underlying short-term and long- term synaptic plasticity? (i.e. where do they occur, how do they occur, and clearly specify the unique cellular mechanisms contributing to LTP that do not occur in short term plasticity).