What is the importance of N-linked glycosylation for glycoproteins in general? And, what is the importance of the N-linked glycan structure for antibody functions?

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Patrina SchowalterLv2

9 Nov 2018

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Glycans that are conjugated to lipids or proteins play roles other than as energy store in cells. With use an example for each, suggest the cellular localizations of glycocolipids and glycoproteins and biological functions of the glycan moieties of these glycoconjugates.

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I understand that mass spec is widely used to study PTMs likeglycosylation of proteins, but how can mass spec determine correctPTM structure of say glycosylation if two glycan structures havethe same mass but different arrangement (i.e. isobaric)? Also, howcan mass spec determine the difference between structuralisomers?

Mark the correct statements about glycan structure and biogenesis. Question options: Explain why if at all possible, please.

A.) Glycosyltransferases are enzymes which attach sugar moieties to proteins, lipids, and glycans.

B.) Glycosyltransferases make use of a template which directs attachment of sugars.

C.) Lectins are enzymes which remove glycans through hydrolysis reactions.

D.) The rigid structure of cellulose and chitin is due to an extensive network of hydrogen bonds.

E.) Cellulose consists mainly of disaccharides linked by beta-1-4 glycosidic bonds. N-acetyl glucosamine is a disaccharide consisting of glucose and fructose.

F.) Chitin is a branched glycan which mediates cell-cell interactions.