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• What is a haptotype? __ Because the MHC genes are closelylinked, inheritance for the grouping is known as a haplotype.

• Explain what a haplotype is in regard to inheritance of MHCantigens

• Describe differences in structure of Class I and Class IIproteins

• Compare the transport of antigen to cellular surfaces by classI and class II protein

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Reid Wolff
Reid WolffLv2
28 Sep 2019

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Related questions

Which of the following is false regarding MHC molecules?

A.

Professional antigen-presenting cells are the only cells in the body that express class II MHC molecules

B.

The vertebrate MHC locus encodes multiple class I and class II MHC genes as well as components of the complement cascade and the antigen-processing machinery

C.

Class I MHC molecules are present on most, if not all, nucleated cell membranes

D.

T cells specifically and exclusively recognize antigen in complex with class II MHC

Description

Both Immunoglobulins and the proteins of the MHC complex are capable of recognizing a very broad range of proteins or peptides associated with pathogens. Their methods of establishing this wide repertoire of recognition is established at the genetic level, but have no similarities in the processes.

Instructions

Describe the genes of both these effectors, characterizing the steps in the generation of this diversity in Immunoglobulins. Describe the inheritance of MHC genes and how these genes are expressed and regulated. You should include your explanation of polygeny and polymorphism as it relates to the MHC haplotype of an individual, and also include explanation of affinity maturation and somatic hypermutation with your description of immunoglobulins.

Immunology worksheet help?

1. In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon?
A. TAP
B. Ii
C. TCR
D. CLIP
E. RAG
2. Your chances of having the same MHC haplotype as your siblingare:
A. 1:2.
B. 1:4.
C. 1:16.
D. 1:8.
E. 1:1.
3. Which of the following is the BEST example of self-MHCrestriction of T cells?
A. A T-cell clone is deleted when it binds too tightly to selfMHC.
B. A T-cell clone responds more vigorously to a self-peptide thana foreign peptide.
C. A T-cell clone recognizes foreign MHC.
D. A T-cell clone only recognizes foreign peptides when presentedby self MHC.
E. All of the above
4. MHC molecules:
A. are conserved between individuals.
B. bind repeating patterns found on pathogens.
C. are recognized by T cells.
D. are membrane-bound molecules found exclusively on T cells.
E. are secreted by T cells and bind and neutralize antigen in theserum.
5. Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this?
A. They would compensate for low diversity in the MHC with highdiversity in the TCR.
B. They would compensate for low diversity in the MHC with highdiversity in the BCR.
C. They would rely only on innate immune responses.
D. They would be at higher risk of infection.
E. All of the above
6. How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress?
A. Six
B. Two
C. Three
D. One
E. None. Only APC express class I.
7. MHC polymorphisms tend to cluster:
A. in the peptide-binding groove.
B. in the transmembrane domain.
C. in the coreceptor contact residues.
D. in the framework region.
E. All of the above
8. A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to:
A. cells with no class II MHC.
B. a deficiency in CD8+ T cells.
C. cells with class II MHC only bound with CLIP.
D. cells with class II MHC bound with a variety ofself-antigens.
E. cells with no DO.
9. The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean?
A. This region is regulated by many different mechanisms.
B. Sequence variability is low in this region.
C. There are many introns in this region.
D. There are many different alleles of these genes.
E. It has the most different genes.
10. Which of the following is an example ofcross-presentation?
A. An exogenous peptide being presented on MHC class II
B. A B-cell antigen being presented to a T cell
C. An endogenous peptide being presented on MHC class I
D. An endogenous peptide being presented on MHC class II
E. An exogenous peptide being presented on MHC class I

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