Explain how cyclin and cyclin-dependent kinases regulate progression through the cell cycle and various checkpoints
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Different cyclin-dependent protein kinases (CDKs) regulate the transition of eukaryotic cells from one phase of the cell cycle to another: from G1 to S, S to M, or M to G1. Describe the different mechanisms by which the enzyme activity of the CDKs is regulated over time during the cell cycle
Discuss the direct molecular consequences of increased cyclin E levels to cell cycle progression; saying "increased proliferation" is insufficient.
Briefly describe how transcription, phosphorylation, protein-protein interactions and proteasome-mediated turnover are involved in cell cycle regulation (like G1,S,G2,M Phases).
I understand that phosphorylation is related to to cyclin dependent kinases (CDKs), but unsure about the rest. Is the proteasome part related to ubiqutin in some way?