Log in
Biology
2
answers
0
watching
33
views

A. Histone modifications

i. What are some of the basic trends?

ii. Does the same histone modification always have the same effect on transcription?

B. Inheritance of histone modifications

i. Which histones go into the general pool? Which go into the local pool and how much of the newly replicated DNA have these modified histones?

ii. If only have of the proteins

Watch
2
answers
0
watching
33
views

For unlimited access to Homework Help, a Homework+ subscription is required.

Unlock all answers

Get 1 free homework help answer.
Already have an account? Log in
Share
Irving Heathcote
Irving HeathcoteLv2
28 Sep 2019
Already have an account? Log in
Share

Related textbook solutions

Molecular Cell Biology
8 Edition,
Lodish
ISBN: 9781464183393
Biology: Science for Life with Physiology
6 Edition,
Belk
ISBN: 9780134555430
Biology
2nd Edition, 2013
Openstax
ISBN: 9781947172517
Concepts of Biology
OER Edition,
Openstax
ISBN: 9781938168116
Essentials of Biology
5 Edition,
Mader
ISBN: 9781259660269

Related questions

17. Which histone is required to compact the “beads on a string” chromatin into higher-order chromatin structures such as the 30 nm fiber?

18. Certain lysine amino acids (K’s) in the core histone tail can be acetylated. How would this chemical modification of the nucleosome affect the transcription of a gene?

19. Certain protein/protein complexes do not bind DNA, but regulate processes such as transcription and replication. These proteins can associate with the chromatin by recognizing chemical modifications in the core histone tails of the nucleosome. This process represents the “histone code”. Separately, a protein that folds into its three-dimensional functional structures can have different domains with different functions. Assume that a certain protein that increases transcription does not recognize a specific DNA sequence, but rather associates with acetylated lysine amino acids in the histone tails. What domain in this protein would allow it to associate with these acetylated lysine amino acids?

Synergism in transcriptional regulation occurs when two transcription factors have a much greater effect when they are both active than would be predicted if one added their individual effects.
A. True
B. False

The N-terminal region of histones extends from nucleosomes. These histone tails can be covalently modified to signal that a gene in the region should be transcribed. What is the covalent modification?
A. Adding a poly A tail
B. Adding acetyl groups
C. Removing acetyl groups
D. Removing a poly A tail

You are studying how the estrogen receptor regulates expression of a particular gene in breast cancer cells grown in a test tube. You examine cells grown in the presence of estrogenic hormones. Using various biochemical techniques, you find that the activated estrogen receptor [i.e., with hormone(s) bound] binds to cis regulatory sequences in the gene of interest and recruits (physically interacts with) a protein that has histone deacetylase activity. Based on this information, do you predict that estrogen hormones induce transcription, have no effect on transcription, or suppress transcription of the target gene?
A. No effect
B. Induce
C. Suppress

QUESTION 10

If you can drink milk as an adult, it means that you have inherited a mutation in the promoter of your lactase gene (the gene that encodes the enzyme you need to break down lactose). Predict the effect of this mutation:

The mutation changes the number of domains in the enzyme, which makes it work more efficiently

The mutation changes the amino acid sequence of the lactase protein

The mutation increases the number of copies of the lactase gene that will be found in your genome

The mutation changes whether the lactase sequence is found in an intron or exon

The mutation affects the expression of the lactase gene

1.2 points

QUESTION 11

A competitive inhibitor is decreasing the activity of an enzyme. Predict the effect of adding more substrate to the reaction.

The substrate will increase the reaction rate by binding to the allosteric site

The substrate will increase the reaction rate by competing with the inhibitor for the active site

The reaction rate will not change unless the inhibitor can be removed

The enzyme adjusts its shape so that the substrate, but NOT the competitive inhibitor, can bind

The substrate will bind to the competitive inhibitor and block its ability to bind to the enzyme

1.2 points

QUESTION 12

What determines where in the genome a transcription regulator will bind?

Transcription regulators bind to the 5' UTR region of a gene

Regulators bind via complementary base-pairing to certain DNA molecules

Covalent bonds form between the transcription regulator and the atoms of the DNA backbone

Every eukaryotic gene has a different transcription regulator that will bind to the 5' end of the gene

Transcription regulators bind to specific DNA sequences via multiple weak non-covalent interactions

1.2 points

QUESTION 13

What is the basic premise of cell theory?

DNA -> RNA -> protein

All cells arise from pre-existing cells

DNA provides the complete instructions to create a cell

The identity of a cell is determined through gene expression patterns

All cells contain the same four basic macromolecules

1.2 points

QUESTION 14

What is the benefit of using BOTH the lac activator and the lac repressor to control gene expression?

Using both an activator and repressor enables cells to more accurately determine the amount of lactose available in the environment

Enzymes to digest lactose are only made when energy is low and lactose is available

The activator can override the inhibition of the lac operon by the repressor

The repressor can control the enhancer, while the activator can control the promoter

When neither the lac activator or repressor is present, expression of the lac operon is too high

1.2 points

QUESTION 15

What is the histone code used for?

Phosphorylation and acetylation of DNA affect its ability to be compacted

Changes to the sequence of DNA change whether DNA will wrap around histone proteins

Covalent modifications of histones affect the ability of the transcription initiation complex to form

Histones provide the codon sequences needed for translation to occur

The histone code affects which amino acids will get added to a polypeptide

Weekly leaderboard

Home
Homework Help 3,900,000
Biology 460,000
Start filling in the gaps now
Log in