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1. 2,3-biphosphoglycerate (BPG) regulates high altitude adaptation. The BPG concentration increases from 5 mM at sea level to 8 mM at an altitude of 4500 m in human blood. Please explain how our blood manages to transport enough oxygen at high altitude. If the BPG concentration does not change, how much less oxygen can the blood transport at 4500 m compared to at sea level? (Answer these questions according to the binding curve of hemoglobin for O2 at different BPG concentration). A mutation of hemoglobin reduces the binding affinity of BPG, how will this mutation affect oxygen binding and the oxygen binding curve?

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Nelly Stracke
Nelly StrackeLv2
28 Sep 2019
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fill the blanks with the terms given

Terms: 0.21, 21, 78, 760, altitude, blood, Boyle's, Dalton's,decimal, decreased, diaphragm, directly, external intercostal,Henry's, into, inverse, lowers, out of, oxygen, parasternal,partial, percent concentration, pressure, solubility, temperature,total, volume

_________ law states that there is a/an ________ relationshipbetween [listed alphabetically] the _________ of a gas and the___________ of the gas. That is, an increase in one of the factorsis associated with a decrease in the other factor and vice versa.Thoracic cavity size determines the volume of the air in the lungs.Thus, this law is fundamental to explaining why an increase in thethoracic cavity size due to expansion of the rib cage in thehorizontal [front-to-back and side-to-side] directions viacontraction of the ___________ and _________ muscles, (listedalphabetically) and vertical [up-and-down] direction viacontraction of the ___________ causes a resultant decrease inintrapulmonary pressure, creating a pressure gradient that drivesair _____________ the lungs. Conversely, it explains why when thesize of the thoracic cavity is _________ by relaxing the musclesused during inspiration, the pressure of the gas in the lungsincreases, exceeding atmospheric pressure, creating a pressuregradient that then forces air _________ the lungs ________ lawstates that the _______ pressure of a mixed gas is equal to the sumof the ___________ pressures exerted by each of the individualgasses in the mix, which are exerted independent of one another.This law is important to pulmonary physiology because theatmospheric air we breath is a mixed gas that contains roughly__________% nitrogen and _______% oxygen. Moreover, according toHenry's law, it is the partial pressure of the oxygen in the air webreath that is the main determinant of how much of the air's oxygenwe can drive into our blood and make available to the body. A gas'spartial pressure can be calculated by multiplying the totalpressure of the mixed gas by the gas's ____________ in the mixedgas. Thus, the partial pressure of oxygen, at sea level isdetermined by multiplying total atmospheric pressure at sea level -which equals ___________ millimeters of mercury (denoted mm Hg) by________ - oxygen's percent concentration in atmospheric air,expressed as a ____________. ________ law actually states that theamount of gas we can drive into solution is _________ dependentupon 3 factors. These 3 factors are 1) the solubility of theparticular liquid for the particular gas you are considering, 2)the temperature (more gas can be driven into liquids at lowertemperatures than at higher temperatures) and 3) the partialpressure of the gas under consideration. In the body, theparticular gas we are interested in driving into a fluid is__________ and the particular fluid we are interested in drivingthe gas into is our ___________. Because blood has a particularsolubility for oxygen - and this is constant, and because thehomeostatic mechanisms in the body keep body temperature relativelyconstant, this means the single most important factor thatdetermines how much oxygen can be driven in to our blood is thepartial pressure of the oxygen in the air we breath. At sea level -the partial pressure of oxygen in atmospheric air = 760 x 0.21 =159 mm Hg. However, if one climbs to the peak of Mt. Everest, wherethe air is still a mixed gas that contains only ~21% oxygen, butthe air there is 'thinner' i.e. there is just less of it up there,the total pressure of the gas drops to about 250 mm Hg, whichsignificantly __________ the the partial pressure of oxygen and theamount of air that can be forced into the blood at that altitude.Thus this gas law explains why many individuals initiallyexperience ____________ sickness when they vacation in the Rockiesor the Swiss Alps but normally live at much lower elevations.

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