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Two SNPs are in absolute linkage disequilibirum. SNP1 has allele frequencies of 70% T and 30% C, and SNP 2 has allele frequencies of 30% A and 70% T. Calculate the observed frequencies of haplotypes in this population.

The answer is 30% CA and 70% TT, but I don't understand where this came from.

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Patrina Schowalter
Patrina SchowalterLv2
28 Sep 2019

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Related questions

1. Researchers studying a small milkweed population note that some plants produce a toxin and other plants do not. They identify the gene responsible for toxin production. The dominant allele (T) codes for an enzyme that makes the toxin, and the recessive allele (t) codes for a nonfunctional enzyme that cannot produce the toxin. Heterozygotes produce an intermediate amount of toxin. The genotypes of all individuals in the population are determined (TT = 0.56; Tt = 0.28; tt = 0.16) and used to determine the actual allele frequencies in the population. Is this population in Hardy-Weinberg equilibrium? Calculate the T and t.

I already know the answer is "No, there are more homozygotes than expected", but I do not understand how to find this answer. SHOW WORK.

1) In a randomly mating population of fence lizards, haplotype frequencies at the A and B loci are as follows: 60% AB, 10% aB, 10% Ab, 20% ab.

a) Calculate the coefficient of linkage disequilibrium in this population.

b) From your answer, can you infer whether the A and B loci are on the same chromosome?

c) If the population had the same allele frequencies but no linkage disequilibrium, what would be the frequency of the AB haplotype?

You genotype a C/T SNP from a sample of narwhals (Monodon monoceros) from the arctic at two locations, Canada and Siberia, and get the following genotype frequencies.

Canada

c-/c- 9

c+/c- 26

c+/c+ 30

Siberia

c-/c- 28

c+/c- 32

c+/c+ 15

A) What is the frequency of the c- allele in each population?

B) What fraction of heterozygosity is missing (FIS) in each population?

C) What is the average of the expected frequency of heterozygotes over all populations (HS)?

D) What is the average allele frequency over all populations?

E) What is the total expected heterozygosity frequency (HT)?

F) What is the fraction of heterozygosity missing due to differences in allele frequencies between populations (FST)?

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