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Calculate the size of your PCR products for a woman who is heterozygous for a 40-polyglutamine repeat disease allele (120 bases in length), and a 23-polyglutamine non-disease- allele repeat (69 bases in length).

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Casey Durgan
Casey DurganLv2
28 Sep 2019

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Related questions

1. An occurrence of a gene made larger by trinucleotide repeats is:

Allelic expansion

Nucleotide expansion

Translocation mutation

Transformation

2. a chemical that can damage and/or change DNA is called a/an:

Allele

Endonuclease

Vector

Mutagen

3. An occurrence when a section of a chromosome relocates itself to an entirely different (non-homologous) chromosome is called a/an:

Inversion mutation

Translocation mutation

Transformation mutation

Duplication mutation

4. The tandem repeat in the sequence GGGAAGGGAAGGGAAGGGAAGGGAAG is:

GGA

GGGAA

GGAAG

GGAAGGG

A disease characterized by abnormally shaped hemoglobin is called:

Cystic Fibrosis

Sickle Cell Anemia

Marfan Syndrome

Leukemia

5. A point mutation that causes a substitution of a stop codon with an amino acid and leads to the formation of a longer protein is a:

Nonsense mutation

Missense mutation

Sense mutation

Frameshift mutation

6. Addition or deletion of nucleotides in a DNA sequence is known as a:

Nonsense mutation

Missense mutation

Sense mutation

Frameshift mutation

7. The least severe type of chromosomal mutation is:

Point

Frameshift

Inversion

Translocation

8. Chemicals inserting themselves into DNA can cause a:

Missense mutation

Nonsense mutation

Sense mutation

Frameshift mutation

9. A genetic condition caused by allelic expansion is:

Familial hypercholesterolemia

Fragile X syndrome

Alkaptonuria

Galactosemia

10. Which of the following is most likely the original DNA strand if the mutated DNA strand is ATAGUUGATGUA ?

ATAGAAGATGAA

ATAGCCGATGCA

ATAGGGGATGGA

ATAGTTGATGTA

11. An unbalanced chromosomal mutation would include a/an:

duplication (insertion)

inversion

translocation

denaturation

12. Many translocation mutations are found to be involved with:

cancers

sickle cell anemia

Huntington disease

cystic fibrosis

13. A common repeat throughout the human genome that is approximately 300 bases in length is called a/an:

EcoRI repeat

Hind repeat

Exo repeat

Alu repeat

14. A balanced chromosomal mutation includes:

imprintation

denaturation

inversion

deletion

Sickle-cell anemia is caused by a mutation in the b-globin gene.Heterozygotes for the Hbs disease allele have someprotection from malaria relative to wild-type, but Hbshomozygotes rarely live to produce offspring. 50 individualshomozygous for the normal (non-disease) allele produced a total of47 children. 50 heterozygous individuals produced a total of 55children. 50 Hbs homozygous individuals produced a totalof 0 children. What is the average fitness per individualof the heterozygotes? What is the relative fitness of thehomozygous normal individuals?

Cystic fibrosis in an autosomal recessive disease in humans. Mr. and Mrs. Doe are both heterozygous for a low penetrance disease allele, CFTR Arg117His. The estimated penetrance of the disease is 10%. What is the likelihood that their first child will not be affected?

The answer is 97.5% but I do not understand how. Please show me!

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