The Hardy-Weinberg equation provides a way to predict genotype frequency based on allele frequency. In the case of mammals, males are hemizygous for X-linked genes, whereas females have two copies. Among males, the frequency of any X-linked trait equals the frequency of males with the trait. For example, if an allele frequency for an X-linked disease-causing allele was 5%, then 5% of all males would be affected with the disorder. Female genotype frequencies are computed using the Hardy-Weinberg equation.
Consider the human X-linked trait known as hemophilia A. In human populations, the allele frequency of the hemophilia A allele is approximately 1 in 10,000, or 0.0001. The other allele for this gene is the normal allele. Males can be affected or unaffected, whereas females can be affected, unaffected carriers, or unaffected noncarriers.
A. What are the allele frequencies for the mutant and normal allele in the human population?
B. Among males, what is the frequency of affected individuals?
C. Among females, what is the frequency of affected individuals and heterozygous carriers?
The Hardy-Weinberg equation provides a way to predict genotype frequency based on allele frequency. In the case of mammals, males are hemizygous for X-linked genes, whereas females have two copies. Among males, the frequency of any X-linked trait equals the frequency of males with the trait. For example, if an allele frequency for an X-linked disease-causing allele was 5%, then 5% of all males would be affected with the disorder. Female genotype frequencies are computed using the Hardy-Weinberg equation.
Consider the human X-linked trait known as hemophilia A. In human populations, the allele frequency of the hemophilia A allele is approximately 1 in 10,000, or 0.0001. The other allele for this gene is the normal allele. Males can be affected or unaffected, whereas females can be affected, unaffected carriers, or unaffected noncarriers.
A. What are the allele frequencies for the mutant and normal allele in the human population?
B. Among males, what is the frequency of affected individuals?
C. Among females, what is the frequency of affected individuals and heterozygous carriers?
