Question

Which of the followingstatements comparing the targeting of a mitochondrial matrixprotein to the targeting of a protein to the ER is/are correct?Choose all that apply.

-Proteins translocated into either compartment have an equalchance of ultimately being localized to the outside of thecell.

-Insertion of proteins into both compartments takes advantage ofan energy source in the form of an electrochemical gradient.

-Proteins destined for either compartment require sequences ofamino acids which serve as targeting signals.

-Proteins destined for either compartment are inserted intotheir respective compartments in an unfolded state.

-The same signal can be used to direct a protein to eithercompartment, as long as the appropriate receptor recognizes thesignal.

-Proteins destined for either compartment are allowed to foldin the cytoplasm and then are unfolded prior to insertion intotheir respective compartments.

-Proteins destined for either compartment are likely to retaintheir amino terminal targeting signals.