answer

watching

views

3 Jun 2019

Draw the synthesis of an N-glycosylated, integral membrane protein with 3 transmembrane regions, destined for the plasma membrane. (Start with mRNA in the nucleus and end with the protein in the plasma membrane. You do not have to describe all the glycosylation steps, just what is happening in general and where.) In your diagram, be sure to explain with words or show why the carbohydrate groups of membrane glycoproteins always found on the outer surface of the plasma membrane? Think protein expression, not protein function. Be sure to include the different types of protein modifications in the different organelles.

How would this differ for DNA polyermerase?

How would this differ for a soluble protein that functions in the ER that is also methylated?

answer

watching

171

views

For unlimited access to Homework Help, a Homework+ subscription is required.

You have 0 free answers left.
Get unlimited access to 3.8 million step-by-step answers.

Get unlimited access

Already have an account? Log in

Elin HesselLv2

6 Jun 2019

Unlock all answers

Get 1 free homework help answer.

Already have an account? Log in

Related questions

6. True or false

a_______ Nuclear pore complexes are specialized so that some mediate import and others mediate export

b_______ Membrane-bound and free ribosomes, which are structurally and functionally identical, differ only in the proteins they happen to be making at a particular time.

c_______ Some proteins can be made as either free or membrane-bound proteins. They have the same mRNA but different splicing and poly-adenylation patterns

d_______ a protein that does not have a sorting signal will be tagged for destruction by ubiquitin

e_______ when the hydrophobic signal peptide emerges from the ribosome, it is bound by SRP, which causes a pause in protein synthesis. Synthesis resumes when the ribosome with a bound SRP then binds to the SRP receptor on the cytosolic surface of the rough ER.

f________ A protein cannot leave the ER unless it is correctly folded

g________ All of the glycoproteins and glycolipids in intracellular membranes have their oligosaccharide chains facing the cytosolic side, and all those in the plasma membrane have their oligosaccharide chains facing the outside of the cell.

1. Name two similarities and two differences between thecellular processes of importing

protein into the ER and importing protein to the nucleus.

2. What proteins are directly involved in the transportation ofcargo in a clathrin-coated

vesicle?

a. Dynamin

b. Adaptins

c. Cargo receptors

d. t SNARES

3. Suppose a cell was treated with colchiine, a drug causingmicrotubule disassembly.

What would happen within the cell? Why?

Suppose there were a genetic defect in the genes that code forkinesins and dyneins.

What would happen within the cell? Why?

4. Which of the following are true about microtubules?

a. They are utilized by the disease causing bacteriaLysteria.

b. Instability in the minus-end of the microtubule is caused bythe hydrolization of GTP.

c. Centrosomes contain binding sites for microtubules composed atype of tubulin ring.

d. Cellular concentrations of tubulin are above the criticalconcentration for plus-end

polymerization.

e. Motor proteins can attach organelles to the microtubules.

5. Indicate which of the following statements are false:

a. Membrane fusion is energetically unfavorable and thusrequires ATP or similar high

energy molecule to occur

b. Clathrin is responsible for capturing specific molecules fortransport in coated vesicle

structures.

c. Receptor proteins that are incorporated into an endosome canbe retrieved back to the

membrane domain it originated from; can return to a new domainof the membrane; or

can enter the lysosome for digestion.

d. Transport vesicles occasionally bud from the trans Golginetwork to fuse with the

plasma membrane in a process called constitutive exocytosis.

e. Most components of the endocytic vesicle membrane eventuallyare returned to the

plasma membrane for reuse.

6. Match the following organelles with their function:

Organelle Bank:

a. Mitochondria

b. Endoplasmic reticulum

c. Nucleus

d. Lysosome

e. Endosome

f. Peroxisome

g. Golgi apparatus

_____ quality control of mRNA

_____ location of oxidative phosphorylation

_____ responsible for detoxifying organic molecules (livercells)

_____ houses and protects genetic material

_____ responsible for modification and sorting of proteins andlipids

_____ location of ATP synthesis

_____ responsible for sorting endocytosed materials

_____ site of degradation and digestion

_____ responsible for oxidizing toxic molecules

_____ location of lipid synthesis

_____ location of hormone synthesis (adrenal cells)

B. Which organelle(s) from the above list communicate(s) withother organelle(s)

through the use of vesicular transport? ________________

C. Which organelle(s) from the above list receive proteins madein the

cytosol?___________________

D. Through which organelle(s) must proteins pass to reach theorganelle(s) which do not

receive proteins made exclusively in thecytosol?______________

E. Entrance into which organelle(s) requires that proteinsunfold and snake through the

membrane? _________________

F. How do organelles maintain their position in the cytosol? Bespecific.

G. Give 2 advantages that eukaryotic cells gain by havingorganelles.

7. Which of the following statements are true regardingactin?

a. They are arranged in a

crimsonwalrus870

Question 401 pts

Kinetic energy is the stored energy that can be used for motion.

True

False

Flag this Question

Question 411 pts

When an electron is transferred from one atom to another, and the two atoms are then electrically attracted to one another, a(n) ________________ bond is formed.

Flag this Question

Question 421 pts

Changing the number of ____________ of an atom would change the chemical properties of the atom.

Flag this Question

Question 431 pts

Forming molecules and breaking down molecules in biological organisms usually requires the use of _________ to help the reaction proceed faster.

Flag this Question

Question 441 pts

Organic molecules have a core composed of .

Flag this Question

Question 451 pts

The building blocks of carbohydrates are

Flag this Question

Question 461 pts

Water molecules crossing a membrane from high to low concentration is .

active transport

cell fate

facilitated diffusion

osmosis

Flag this Question

Question 471 pts

Choose the membrane molecule responsible for the passage of polar molecules and ions into and out of the cell.

phospholipids

transmembrane channel proteins

cell surface proteins

carbohydrate chains

Flag this Question

Question 481 pts

The simplest cells are .

Flag this Question

Question 491 pts

Which of the following membrane bound organelles are found inside bacterial cells:

nucleus

organelles are not found in prokaryotic cells

mitochondria

chloroplasts

Flag this Question

Question 501 pts

Which of the following is a specialized components of the cell, is associated with the rough endoplasmic reticulum, and is responsible for making proteins.

Flag this Question

Question 511 pts

Proteins are sorted, modified, and packaged by the _____________ and later transported to the outside of the cell.

ribosomes

golgi bodies (golgi apparatus)

nucleus

mitochondria

Flag this Question

Question 521 pts

Dehydration synthesis is a process of linking two smaller subunits together to form a polymer. Which of the following statements below is true of dehydration synthesis?

Oxygen is consumed.

A water molecule is removed from the molecules.

A water molecule is added to the molecules

Carbon dioxide is given off.

Flag this Question

Question 531 pts

Proteins are made up of _________ held together by peptide bonds.

Flag this Question

Question 541 pts

Which of the following gives an amino acid its properties?

NH2

R Group or functional group

COOH

Flag this Question

Question 551 pts

The final three-dimensional shape of a protein that includes the bonding of two or more polypeptide chains is call its _____ structure.

Flag this Question

Question 561 pts

How do DNA and RNA differ?

all statements are differences between DNA and RNA.

DNA is double stranded while RNA is single stranded.

They have different sugars.

Thymine is present in DNA but not in RNA.

Flag this Question

Question 571 pts

Which of the following is a component of a DNA nucleotide?

phosphate

a nitrogen containing base

All are components of a nucleotide.

5-carbon sugar

Flag this Question

Question 581 pts

Cell membranes are made up of several different types of molecules. Select the membrane molecule below that is made up of a polar region and two non-polar fatty acid tails.

transmembrane proteins

carbohydrate chains

phospholipids

cell surface proteins

Flag this Question

Question 591 pts

Two organelles which are believed to have once been free-living bacterial cells are ____________ and ______________.

chloroplasts and mitochondria

golgi apparatus and endoplasmic reticulum

ribosomes and nucleolus

peroxisomes and lysosomes

Flag this Question