As a scientist involved in gene therapy, you have been asked to develop gene therapy vectors based on one of these viruses to treat Parkinsonâs disease and other diseases of the nervous system.
Which virus would you use as a gene therapy vector? Clearly explain why you picked this virus based on what you know about the replication cycle of the virus.
How would you design this vector? Think about where in the genome of the virus would you insert the transgene to be delivered to the nervous system and why?â
As a scientist involved in gene therapy, you have been asked to develop gene therapy vectors based on one of these viruses to treat Parkinsonâs disease and other diseases of the nervous system.
Which virus would you use as a gene therapy vector? Clearly explain why you picked this virus based on what you know about the replication cycle of the virus.
How would you design this vector? Think about where in the genome of the virus would you insert the transgene to be delivered to the nervous system and why?â
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1. A mutation in the gene encoding the integrase enzyme rendersthe protein non-functional. How would the affect the HIV infectioncycle?
Formation of the provirus would bestopped. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Reverse transcription would nolonger be possible. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The gp120 glycoprotein would nolonger be able to bind to the CCR5 receptor. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cutting and assembling the capsid would be halted. 2. If the viral gene is AUGCCCAGG and the mRNA used to make theviral protein is UACGGGUCC, then the virus is a :
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QUESTION 1: The rabies virus primarily affects the nervous system. The specificity that the rabies virus has for neuronal host cells is primarily dictated by __________________________.
A. the helical shape of its viral capsid |
B. the type of nucleic acid used for its viral genome (single-stranded, antisense RNA) |
C. the spikes that protrude from its viral envelope |
D. the segmented nature of its viral genome |
QUESTION 2: Which of the following genome types has been observed in viruses? To be marked correct, you'll need to select all true statements, as there may be more than one correct answer.
A. Single-stranded RNA |
B. Single-stranded DNA |
C. Double-stranded RNA |
D. Protein-based |
QUESTION 3: Choose the correct statement about viral evolution.
A. RNA and DNA viral genomes evolve at equal rates. | ||||||||||||
B. Cellular genomes mutate at a faster rate than viral genomes due to their large size and increased chance of replicative mistakes. | ||||||||||||
C. DNA viruses mutate faster than RNA viruses because thymine is more susceptible to mutation than uracil. | ||||||||||||
D. RNA viruses mutate faster than DNA viruses due to a lack of proofreading replicative enzymes. QUESTION 4: Your elderly patient is affected by shingles. After careful observation, you note that the virus responsible for the infection has an icosahedral capsid, is enveloped, and has double-stranded linear DNA as its genetic material. Based on this information, in which of the following viral families would you group this viral pathogen?
QUESTION 5: Which of the following is a key difference between lytic and lysogenic bacteriophage replication cycles?
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