Given the following diagram of how protein Awesome1 binds to its target DNA, describe the potential affects of each of the 5 mutations shown below. The wild-type sequence of alpha helix #1 is
R (1)-V-I-L-Y-F-W-I-M-Y-F-S-H-Y-W-R (16).
Predict the consiquences of the following mutations:
1. Arg(1) to Glu
2. Arg(1) to Ala
3. Phe(6) to Ile
4. Trp (8) to Phe
5. Met(9) to Pro
Given the following diagram of how protein Awesome1 binds to its target DNA, describe the potential affects of each of the 5 mutations shown below. The wild-type sequence of alpha helix #1 is
R (1)-V-I-L-Y-F-W-I-M-Y-F-S-H-Y-W-R (16).
Predict the consiquences of the following mutations:
1. Arg(1) to Glu
2. Arg(1) to Ala
3. Phe(6) to Ile
4. Trp (8) to Phe
5. Met(9) to Pro
Related textbook solutions
Related questions
For the following strand of DNA, use the table below to provide: bases for the complementary mRNA and the associated amino acids. What do you notice about the genetic code for proline in the peptide? How would the loss of the first G or switching that G to a T affect the structure and function of this protein?
DNA: GGC CTA CAA GCC GGA ACA GTT ACC GCG TAA CGA
RNA: ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ???
Amino Acid:??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ???
(3 Letters)
Genetic Code Table (mRNA)
| 1st position (5' end) | 2nd position (middle) | 3rd position (3' end) | |||
| U | C | A | G | ||
| U | Phe F Phe F Leu L Leu L | Ser S Ser S Ser S Ser S | Tyr Y Tyr Y STOP STOP | Cys C Cys C STOP Trp W | U C A G |
| C | Leu L Leu L Leu L Leu L | Pro P Pro P Pro P Pro P | His H His H Gln Q Gln Q | Arg R Arg R Arg R Arg R | U C A G |
| A | Ile I Ile I Ile I Met M | Thr T Thr T Thr T Thr T | Asn N Asn N Lys K Lys K | Ser S Ser S Arg R Arg R | U C A G |
| G | Val V Val V Val V Val V | Ala A Ala A Ala A Ala A | Asp D Asp D Glu E Glu E | Gly G Gly G Gly G Gly G | U C A G |
