When a biologist is talking about a genetically engineered mousestrain which is a "tool strain", what does that mean? What is theexact definition of a tool strain? What is the difference between atool strain and any other mouse strain?
Also, how are tool strains connected to recombinase techniques?Does using a recombinase automatically create a tool strain? Or arethe properties "tool strain" and "recombinase containing strain"independent from each other?
If it is important, the context is mouse (and possibly otheranimal) strains used in cancer research.
It would help if you could keep the explanation high-level. Ionly have high-school biology knowledge and I am trying to makesense of the requirements for a software application for use bybiologists.
When a biologist is talking about a genetically engineered mousestrain which is a "tool strain", what does that mean? What is theexact definition of a tool strain? What is the difference between atool strain and any other mouse strain?
Also, how are tool strains connected to recombinase techniques?Does using a recombinase automatically create a tool strain? Or arethe properties "tool strain" and "recombinase containing strain"independent from each other?
If it is important, the context is mouse (and possibly otheranimal) strains used in cancer research.
It would help if you could keep the explanation high-level. Ionly have high-school biology knowledge and I am trying to makesense of the requirements for a software application for use bybiologists.
