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30 Jul 2019

Describe how eukaryotic transcription is regulated bypost-translational modifications to histones and transcriptionfactors.

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Tod Thiel
Tod ThielLv2
2 Aug 2019

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Related questions

- Review the levels of control of gene expression that include:

1. Chromatin structure and role of chemical modifications of DNA and histones, as

the first “on” switch for turning on eukaryotic gene expression. Define the term

epigenetics.

2. Structural components of eukaryotic genes: coding and proximal and distal

regulatory sequences (enhancers and silencers), and their function. Role and

binding sites of transcription factors and activator and repressor proteins.

3. Transcriptional and post transcriptional levels

4. Pre and post translational control levels

Protein synthesis. How are proteins made in cells? Using the central dogma and starting with a gene, describe transcription, translation, and post-translational modifications.

A. Histone modifications

i. What are some of the basic trends?

ii. Does the same histone modification always have the same effect on transcription?

B. Inheritance of histone modifications

i. Which histones go into the general pool? Which go into the local pool and how much of the newly replicated DNA have these modified histones?

ii. If only have of the proteins

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