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24 Nov 2018
50. You are studying how phosphorylation by the Cdc2 kinasecontrols nuclear lamina disassembly during mitosis. You make aseries of mutations in a gene encoding a lamin protein and expressthese mutated lamins inside the cell (ie the cell now makes themutated lamins). You find that when you mutate a serine residue onthe amino terminal domain of the nuclear lamin, the mutated proteinassembles into the nuclear
lamina just fine, but does not depolymerize during mitosis. Suggesta possible reason why this lamin protein might be resistant to Cdc2kinase-mediated disassembly.
50. You are studying how phosphorylation by the Cdc2 kinasecontrols nuclear lamina disassembly during mitosis. You make aseries of mutations in a gene encoding a lamin protein and expressthese mutated lamins inside the cell (ie the cell now makes themutated lamins). You find that when you mutate a serine residue onthe amino terminal domain of the nuclear lamin, the mutated proteinassembles into the nuclear
lamina just fine, but does not depolymerize during mitosis. Suggesta possible reason why this lamin protein might be resistant to Cdc2kinase-mediated disassembly.
Beverley SmithLv2
27 Nov 2018
