What is genomic imprinting? When and how does it occur
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Define de novo methylation, imprinting control region (ICR) and differentially methylated regions (DMR) from genomic imprinting:
why does DNA methylation lead to activation of the Insulin growth factor 2 (Igf2) during genomic imprinting?
compare and contrast the âSymmetry breakâ and âGene silencing and compactionâ stages
METHYLATION
1-What is methylation and where does it usually occur? What effect does it have on gene expression?
2-What is the difference between de novo methylation and maintenance methylation?
3-What is epigenetics, and what is genomic imprinting?
4-Where are promoters usually found on chromatin?
Discuss genomic differences between human males and females andconsequences these difference have.
Hint: Your essay should include a discussion of inheritance ofsex-linked genes, x-inactivation, and genomic imprinting. Giveexamples when appropriate.
