Make a flow-chart with the basic steps of self tolerance generation and In the context of self tolerance generation, how autoimmunity is developed?
Make a flow-chart with the basic steps of self tolerance generation and In the context of self tolerance generation, how autoimmunity is developed?
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Which of the following statements about induction or maintenance of T cell tolerance is NOT true?
| a. | Peripheral T cell tolerance to an antigen may be induced by persistent and repeated stimulation of lymphocytes by that antigen in tissues. | |
| b. | Peripheral T cell tolerance results when T cells recognize antigen in the setting of an innate immune response to the antigen. | |
| c. | Peripheral T cell tolerance to some antigens is induced when mature T cells recognize antigen and bind B7-1 or B7-2 via the inhibitory CTLA-4 receptor. | |
| d. | Peripheral T cell tolerance results when mature naive T cells recognize antigens without adequate B7-1â or B7-2âmediated costimulation. | |
| e. | Central tolerance is induced when immature developing T cells in bone marrow or thymus encounter self-antigens. |
