Noncompetitive inhibition is a limiting case in which the effect of binding inhibitor has no effect on the affinity for the substrate and vice versa. Suggest what a Lineweaver-Burk plot would look like for an inhibitor that had a reaction scheme similar to standard noncompetitive inhibition (shown at right), but where binding inhibitor lowered the affinity of EI for the substrate.
With the first two box options as:
And the last box options as:
KI EI Noncompetitive inhibition is a limiting case in which the effect of binding inhibitor has no effect on the affinity for the substrate and vice versa. Suggest what a Lineweaver-Burk plot would look like for an inhibitor that had a reaction scheme similar to standard noncompetitive inhibition (shown at right), but where binding inhibitor lowered the affinity of El for the substrate. Ks Ks ES ESI The slope of the plot in the presence of the inhibitor willthe slope in the absence of the inhibitor. The I/Vaxis intercept of the plot in the presence of the inhibitor will the intercept in the absence of inhibitor. Plots for separate experiments at different inhibitor concentrations will intersect Submit Answer Try Another Version 2 item attempts remaining
