The side chains of which of the following pairs of amino acid are most likely to be found associated with each other in the hydrophobic core of a globular protein? (select two answers)

1 arginine; glutamic acid

2 phenylalanine, lysine

3 threonine; threonine

4 leucine; leucine

5 alanine; valine

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Nelly StrackeLv2

17 Dec 2019

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Related questions

Using the information in the table below, enter the correct pH that should be used to separate the following three amino acids by electrophoresis:

(a) Glu, Lys, and Thr: pH=?

(b) His, Lys, and Arg: pH=?

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pK_a Values for Ionizable Groups of Amino Acids.
Amino Acid	pK_a of Î±-COOH	pK_a of Î±-NH₃⁺	pK_a of Side Chain	Isoelectric Point (pI)
Alanine	2.35	9.87	-	6.11
Arginine	2.01	9.04	12.48	10.76
Asparagine	2.02	8.80	-	5.41
Aspartic acid	2.10	9.82	3.86	2.98
Cysteine	2.05	10.25	8.00	5.02
Glutamic acid	2.10	9.47	4.07	3.08
Glutamine	2.17	9.13	-	5.65
Glycine	2.35	9.78	-	6.06
Histidine	1.77	9.18	6.10	7.64
Isoleucine	2.32	9.76	-	6.04
Leucine	2.33	9.74	-	6.04
Lysine	2.18	8.95	10.53	9.74
Methionine	2.28	9.21	-	5.74
Phenylalanine	2.58	9.24	-	5.91
Proline	2.00	10.60	-	6.30
Serine	2.21	9.15	-	5.68
Threonine	2.09	9.10	-	5.60
Tryptophan	2.38	9.39	-	5.88
Tyrosine	2.20	9.11	10.07	5.63
Valine	2.29	9.72	-	6.00

1) Assuming the oligopeptide Î±-helix forms one continuous Î±-helix, the carbonyl oxygen of the glutamic acid residue is hydrogen bonded to the amide nitrogen of

a. leucine
b. lysine
c. cysteine
d. isoleucine
e. serine

2) Which of the following mutations would probably be least likely to impact the function of the
protein?

a. Lys to Ala
b. Ala to Asp
c. His to Pro
d. Thr to Ser
e. Ala to Tyr

3) Hydrophobic interactions may occur between the R groups of which of the following amino acids?

a. tyrosine and phenylalanine

b. arginine and histidine

c. glycine and tryptophan

d. valine and asparagine