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13 Dec 2019

What is the peak plasma concentration (Cp) of aspirin in a 97.522 kg man after taking two 325 mg aspirin. The volume of distribution for aspirin is 0.15 L/kg. And F=80% I'm pretty sure the F is the amount that actually goes into the plasma

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Bunny Greenfelder
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17 Dec 2019

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Related questions

Aspirin has the structural formula

At body temperature (37 °C), Ka for aspirin equals 3 × 10-5. If two aspirin tablets, each having a mass of 325 mg, are dissolved in a full stomach whose volume is 1 L and whose pH is 2, what percent of the aspirin is in the form of neutral molecules?


1.The drug LSD has a half-life of 2.5 hours in plasma. What is the rate constant in hr-1? Report to 2 decimals.

2.A drug has a half-life of 4 hours. What is the rate constant in units of min-1? Report to 2 significant figures.

3.The drug amphetamine (molecular weight of 135.2) is often supplied as the phosphate salt of the form B•H3PO4 . If the drug is supplied in tablets that contain 22 mg of the drug salt, what is the amount of the drug itself in 1 tablet(s) in mg? Round to the nearest whole number.

4.The drug amphetamine (molecular weight of 135.2) is often supplied as the phosphate salt of the form B•H3PO4 . The drug is supplied in tablets that contain 23 mg of the drug salt and the bioavailability of the drug is 57%. If a person takes 4 tablet(s), what is the effective dose in mg? Report your result to the nearest whole number.

5.The drug amphetamine (molecular weight of 135.2) is often supplied as the phosphate salt of the form B•H3PO4 . The drug is supplied in tablets that contain 16 mg of the drug salt and the bioavailability of the drug is 41%. If a person takes 2 tablet(s), what is Cp? Assume the volume of distribution is 4.2 L/kg and the person weighs 172lbs. Report in ppb and with 1 decimal place.

6. The LD50 of a given drug is listed as 250mg/kg. How much of this drug would correspond to a lethal dose for a person weighing 173lbs? Report the result in grams to zero decimal places.

7. A drug has a plasma half-life of 2.4 hours. If the peak plasma concentration of this drug is 38.1 μg/L, how much time will elapse before the plasma concentration reaches 10.0 μg/L? Report your result in hours with 1 decimal place.

8. Fentanyl is an opiate that is about 10x as potent as morphine for pain relief. A plasma concentration of 15-20μg/L is usually fatal. A person is found non-responsive with 13 fentanyl patches surrounding them. Each patch has 100μg total fentanyl. Frequently, the patches are scaped and the contents "smoked" to deliver the drug directly to the bloodstream. If this person did so (using all the patches), what would be the peak plasma concentration of fentanyl? Asume the volume of distribution is 4L/kg and the person weighs 140.0lbs. Report in μg/L with 2 significant figures.

9.Fentanyl is an opiate that is about 10x as potent as morphine for pain relief. A plasma concentration of 21.1μg/L is usually fatal. One method of ingestion is to scrape the contents of the patch into a spoon, heat it, and inhale the vaporized drug. If a patch is labeled as delivering 75μg/hr for 66 hours, how many patches would have to be used in this way to reach the fatal peak plasma concentration? Asume the volume of distribution is 4L/kg and the person weighs 140.0lbs. Report to one decimal.

10.A drug that is taken orally reaches peak plasma concentration in 3 minutes and has a half-life of 42 minutes. A person takes enough of the drug to reach a peak plasma concentration of 40.4 μg/L. How long after ingestion of the drug will the plasma concentration reach 37 μg/L? Report your results in minutes, rounded to the nearest minute.

11.Heroin has a plasma half-life of 17 minutes as it rapidly metabolizes 6-monoacetylmorphine and eventually to morphine. Assume some ingests heroin by injection leading to a peak plasma concentration of 124.6μg/L. What will be the plasma concentration of heroin in the same units 44 minutes after injection? Report to the nearest whole number.

12.A drug is supplied in tablets that contain 5.0mg of the drug per tablet. The bioavailablity of this drug is 45%, the plasma half-life is 35 minutes, and the volume of distribution is 3L/kg. The drug is rapidly absorbed and reaches peak plasma concentration 25 minutes after ingestion. If a person weighing 190lbs takes two tablets, what will be the plasma concentration 3 hour(s) after he/she took the tablets? Report your result in ppb to one decimal.

13. A drug is supplied in tablets that contain 5.0mg of the drug per tablet. The bioavailablity of this drug is 64%, the plasma half-life is 41 minutes, and the volume of distribution is 4 L/kg. The drug is rapidly absorbed and reaches peak plasma concentration 39 minutes after ingestion. If a person weighing 207 lbs takes two tablets, what will be the plasma concentration 3 hour(s) after he/she took the tablets? Report your result in ppb to 2 decimals.

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