Question

You are performing an in vitro experiment in which you will expose a material you are
considering for a medical device to synovial fluid, which contains the proteins albumin,
transferrin, and IgM at concentrations of 5, 0.5, and 0.05 mg/ml, respectively. Each of these
components has a particular affinity for your material, with IgM being the highest and
albumin being the lowest.
a. Describe the kinetics of protein adsorption to your material and how the surface
concentration of each protein will change with time.
b. Subsequently in the experiment, more albumin is added to the synovial fluid. What effect
will this have on the proteins adsorbed on the surface?