What is the biochemical explanation for the lethal effects of dintrophenol (DNP) when ingested in large quantities for the purpose of losing weight? Choose the ONE BEST answer.
A. Individuals who injest large amounts of DNP are unable to sustain life on a normal diet so their body begins to consume itself and they die from hyperthermia, which causes spontaneous combustion.
B. DNP blocks redox reactions in Complex IV, which has the same effect of cyanide and leads to death by asphyxiation.
C. DNP dissipates the proton gradient and severly reduces the efficiency of mitochondrial ATP synthesis, which causes liver damage due to accumulation of this hydrophobic molecule in membranes.
D. DNP interferes with expression of UCP1 and the individual is unable to control body temperature, which leads to massive amounts of ATP synthesis and depletion of phosphate in the body.
E. Individuals ingesting large amounts of DNP disrupt metabolism in brown fat and they are unable to keep warm, so they die from hypothermia in their sleep.
F. People who ingest large amounts of DNP become delirious because neuronal membranes disintegrate due to inhibition of the Na+/K+ ATPase channel and loss of membrane potential.
G. DNP binds to and inhibits the beta subunit in the ATP synthase complex, therefore without ATP synthesis, the ETS shuts down and the individual dies from lack of oxidative deamination.
What is the biochemical explanation for the lethal effects of dintrophenol (DNP) when ingested in large quantities for the purpose of losing weight? Choose the ONE BEST answer.
A. Individuals who injest large amounts of DNP are unable to sustain life on a normal diet so their body begins to consume itself and they die from hyperthermia, which causes spontaneous combustion.
B. DNP blocks redox reactions in Complex IV, which has the same effect of cyanide and leads to death by asphyxiation.
C. DNP dissipates the proton gradient and severly reduces the efficiency of mitochondrial ATP synthesis, which causes liver damage due to accumulation of this hydrophobic molecule in membranes.
D. DNP interferes with expression of UCP1 and the individual is unable to control body temperature, which leads to massive amounts of ATP synthesis and depletion of phosphate in the body.
E. Individuals ingesting large amounts of DNP disrupt metabolism in brown fat and they are unable to keep warm, so they die from hypothermia in their sleep.
F. People who ingest large amounts of DNP become delirious because neuronal membranes disintegrate due to inhibition of the Na+/K+ ATPase channel and loss of membrane potential.
G. DNP binds to and inhibits the beta subunit in the ATP synthase complex, therefore without ATP synthesis, the ETS shuts down and the individual dies from lack of oxidative deamination.
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