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Whooping cough is an infection of the respiratory system caused by a toxin from the bacteria Bordetella pertussis. Explain on a cellular level what is happening?

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17 Dec 2019
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Related questions

Just need help with c and d. I already ansered part a and b but I put the questions here as a reference for part c and d.

a) What class of receptors respond to fMLP?

b) Downstream of the activated receptor, PI3Kinase activates Ras and converts PIP2 ro PIP3 5o activate Rac. What kind of biomolecules are these five components?

c) Downstream of these activating signals, two later events occur: transcription is activated by EIk1, and actin reorganization. What kinds of signaling molecules/events lead to each of these, and are they downstream of Rac or Ras? Which event happens faster?

d) Pertussis toxin, known as the causative agent in the illness whooping cough, blocks the activation of Gα​ subunits. How would you expect the addition of this toxin to affect a migrating neutrophil, for example, in a culture dish along with bacteria producing fMLP?

A 65 year old male is having trouble breathing. He is moderately overweight and has been coughing up yellowish phlegm. He smokes two packs of cigarettes a ay and reports having episodes like this for many years

Whooping cough

Chronic bronchitis

Pulmonary edema

Status ashmaticus

A 64 year old male complains about dyspnea and is coughing up blood tinged sputum. Upon auscultation, you notice crackles bilaterally.

Emphysema exacerbation

Pulmonary edema

Pulmonary embolism

Esophageal varices

What nerve primarily controls respiration

Phrenic

Intercostal

Vagus

Thoracic

Which of he following can be present with a sudden onset of difficult breathing and diminished breath sounds

Pertussis

Emphysema

Pneumothorax

Pneumonia

A semi-conscious 34 year old male begins to gag after insertion of an OPA

Suction his air way

Encourage him to cough

Remove the airway and attempt a nasal airway

Remove the airway and insert a smaller size airway

A semi-conscious patient’s dentures have completely loosened.

Apply a nasal cannula

Remove the dentures

Insert an OPA

Reset the dentures in place

What sound would a lower air way obstruction produce

Gurgling

Snoring

Wheezing

Stridor

Which of the following is an indication of an upper airway obstruction

Snoring

Rhonchi

Crackles

Wheezing

Which of the following best describes respiratory difficulty?

Dyspnea

Bradypnea

Apnea

Tachypnea

The epiglottis acts as a

voice box.

filter for microorganisms and debris.

cover over the larynx.

producer of mucus.

ANSWER:

(Level 1, Objective 1)

Collectively, the nose, oral cavity, pharynx, epiglottis, and larynx make up the

nasopharynx.

oropharynx.

laryngopharynx.

upper respiratory system.

ANSWER:

(Level 1, Objective 1)

The cilia present on cells of the lower respiratory system function by:

trapping microorganisms and foreign debris.

propelling microorganisms and particles out.

preventing colonization by potential pathogens.

all of the above.

ANSWER:

(Level 1, Objective 2)

The most common causative agent of a swollen and painful oropharynx is

Streptococcus pyogenes.

Arcanobacterium haemolyticum.

Corynebacterium diphtheriae.

Rhinovirus.

ANSWER:

(Level 1, Objective 3)

Infections associated with cystic fibrosis are due to inflammation of the:

bronchi.

bronchioles.

lungs.

alveoli.

ANSWER:

(Level 1, Objective 3)

A physician sends a nasal washing for viral culture. This specimen is

unacceptable because it is contaminated with upper respiratory flora.

acceptable as long as it contains epithelial cells.

unacceptable if it is for the detection of influenza or respiratory syncytial viruses.

acceptable if it has a thick consistency and is yellow or green in color.

ANSWER:

(Level 2, Objective 4)

A patient is unable to produce adequate sputum for routine, acid-fast, and fungal cultures. The physician may attempt to obtain a/an

induced sputum.

transtracheal aspirate.

bronchoalveolar lavage.

pleural fluid.

ANSWER:

(Level 1, Objective 4)

9. Two throat swabs are received from a 6-year-old female with orders for a rapid screen for group A Streptococcus. One swab is tested using the group A Streptococcus rapid screen, and it is negative. The second swab is used to inoculate

a. sheep blood agar.

b. chocolate agar.

c. no culture is necessary.

d. a and b.

ANSWER:

(Level 1, Objective 6)

Which of the following disease states requires the addition of selective and/or differential medium to ensure recovery of potential pathogens from the respiratory system?

Pertussis

Cystic fibrosis

Laryngitis

a and b

all of the above

ANSWER:

(Level 2, Objective 6)

11. A throat culture provides the following results:

Moderate growth of alpha-hemolytic, catalase-negative, optochin-susceptible, gram-positive diplococci

Heavy growth of alpha-hemolytic, catalase-negative, optochin-resistant, gram-positive cocci

Heavy growth of gamma-hemolytic, oxidase-positive, glucose- and maltose­-positive, gram­ diplococci

You would report

moderate growth of Streptococcus pneumoniae and heavy growth of normal upper respiratory flora.

heavy growth of Streptococcus pneumoniae and heavy growth of normal upper respiratory flora.

heavy growth of Neisseria meningitidis and heavy growth of normal upper respiratory flora.

heavy growth of normal upper respiratory flora.

ANSWER:

(Level 3, Objective 7)

Yeast colonies in a sputum culture are considered significant when they

are present.

comprise 25% of the organisms present.

comprise 50% of the organisms present.

comprise 75% of the organisms present.

ANSWER:

(Level 1, Objective 7)

13. An 8-year-old male presents with a red and sore throat. The rapid group A Streptococcus screen is negative, and a sheep blood agar is inoculated. At 24 hours, there are no beta-hemolytic colonies present and moderate growth of normal upper respiratory flora. At 48 hours, the same culture results are present. Which of the following statements does not explain these results?

a. His sore throat is due to Haemophilus influenzae, and it will not grow on blood agar.

b. The culture was taken very early in the infection.

c. The patient received treatment prior to specimen collection.

d. The causative agent is not bacterial.

ANSWER:

(Level 2, Objective 8)

17. A quantitative bronchial alveolar lavage culture requires:

1. sheep blood agar.

2. chocolate agar.

3. 0.01 mL pipette.

4. 0.001 mL pipette.

a. 1 and 3

b. 1, 3, and 4

c. 2, 3, and 4

d. 2 and 4

ANSWER:

(Level 1, Objective 9)

18. A bronchial washing is plated to a BCYE. This agar should be examined under a laminar flow hood due to the potential for recovery of Legionella pneumophila and

a. Bordetella pertussis.

Francisella tularensis.

mould.

Pneumocystis jiroveci.

ANSWER:

(Level 2, Objective 9)

20. A physician submits a sputum with a culture request for Legionella. Select the growth medium that should be used to cultivate this organism.

a. 7H10

b. TCBS

c. BCSA

d. BCYE

ANSWER:

(Level 1, Objective 6)

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